Abstract: We discuss the experimental prospects for observing processes which violate lepton number (Delta L) in four units ( or more). First, we reconsider neutrinoless quadruple beta decay, deriving a model independent and very conservative lower limit on its half- life of the order of 10(41) ys for Nd-150. This renders quadruple beta decay unobservable for any feasible experiment. We then turn to a more general discussion of different possible low-energy processes with values Delta L >= 4. A simple operator analysis leads to rather pessimistic conclusions about the observability at low-energy experiments in all cases we study. However, the situation looks much brighter for accelerator experiments. For two example models with Delta L = 4 and another one with Delta L = 5, we show how the LHC or a hypothetical future pp collider, such as the FCC, could probe multilepton number violating operators at the TeV scale.