Abstract: We examine the implication of the 750 GeV diphoton resonance on the two-Higgs-doublet model by imposing various theoretical and experimental constraints. The production rate of the two-Higgs-doublet model is smaller than the cross section observed at the LHC by 2 orders of magnitude. In order to accommodate the 750 GeV diphoton resonance, we extend the two-Higgs-doublet model by introducing additional Higgs fields, and focus on two different extensions: an inert complex Higgs triplet and a real scalar septuplet. As the 125 GeV Higgs is in agreement with the observed data, the production rate for the 750 GeV diphoton resonance can be enhanced to 0.6 fb for the former and 4.5 fb for the latter. The results of the latter are well consistent with the 750 GeV diphoton excess at the LHC.