Abstract: We present the first unquenched, continuum limit, lattice QCD results for the matrix elements of the operators describing neutral kaon oscillations in extensions of the Standard Model. Owing to the accuracy of our calculation on Delta S = 2 weak Hamiltonian matrix elements, we are able to provide a refined Unitarity Triangle analysis improving the bounds coming from model independent constraints on New Physics. In our non-perturbative computation we use a combination of N-f = 2 maximally twisted sea quarks and Osterwalder-Seiler valence quarks in order to achieve both O(a)-improvement and continuum-like renormalization properties for the relevant four-fermion operators. The calculation of the renormalization constants has been performed non-perturbatively in the RI-MOM scheme. Based on simulations at four values of the lattice spacing and a number of quark masses we have extrapolated/interpolated our results to the continuum limit and physical light/strange quark masses.