Abstract: We study the impact of large lepton flavor asymmetries on the cosmic QCD transition. Scenarios of unequal lepton flavor asymmetries are observationally almost unconstrained and therefore open up a whole new parameter space for the cosmic QCD transition. We find that for large asymmetries, the formation of a Bose-Einstein condensate of pions can occur and identify the corresponding parameter space. In the vicinity of the QCD transition scale, we express the pressure in terms of a Taylor expansion with respect to the complete set of chemical potentials. The Taylor coefficients rely on input from lattice QCD calculations from the literature. The domain of applicability of this method is discussed.