Abstract: The proposed Deep Underground Neutrino Experiment (DUNE) utilizes a wide-band on-axis tunable muon-(anti) neutrino beam with a baseline of 1300 km to search for CP violation with high precision. Given the long baseline, DUNE is also sensitive to effects due to matter induced non-standard neutrino interactions (NSI) which can interfere with the standard three-flavor oscillation paradigm. Hence it is desirable to design strategies to disentangle effects due to NSI from standard oscillations. In this article, we exploit the tunability of the DUNE neutrino beam over a wide-range of energies to devise an experimental strategy for separating oscillation effects due to NSI from the standard three-flavor oscillation scenario. Using chi(2) analysis, we obtain an optimal combination of beam tunes and distribution of run times in neutrino and anti-neutrino modes that would enable DUNE to isolate new physics scenarios from the standard. We can distinguish scenarios at 3 sigma (5 sigma) level for almost all (similar to 50%) values of delta. To the best of our knowledge, our strategy is entirely new and has not been reported elsewhere.