Abstract: We present DsixTools, a Mathematica package for the handling of the dimension-six standard model effective field theory. Among other features, DsixTools allows the user to perform the full one-loop renormalization group evolution of the Wilson coefficients in the Warsaw basis. This is achieved thanks to the SMEFTrunner module, which implements the full one-loop anomalous dimension matrix previously derived in the literature. In addition, DsixTools also contains modules devoted to the matching to the Delta B = Delta S = 1, 2 and Delta B = Delta C = 1 operators of the Weak Effective Theory at the electroweak scale, and their QCD and QED Renormalization group evolution below the electroweak scale.