Abstract: Treatment planning systems at proton-therapy centres entirely use X-ray computed tomography (CT) as primary imaging technique to infer the proton treatment doses to tumour and healthy tissues. However, proton stopping powers in the body, as derived from X-ray images, suffer from important proton-range uncertainties. In order to reduce this uncertainty in range, one could use proton-CT images instead. The main goal of this work is to test the capabilities of a newly-developed proton-CT scanner, based on the use of a set of tracking detectors and a high energy resolution scintillator for the residual energy of the protons. Different custom-made phantoms were positioned at the field of view of the scanner and were irradiated with protons at the CCB proton-therapy center in Krakow. We measured with the phantoms at different angles and produced sinograms that were used to obtain reconstructed images by Filtered Back-Projection. The obtained images were used to determine the capabilities of our scanner in terms of spatial resolution and proton Relative Stopping Power (RSP) mapping and validate its use as proton-CT scanner. The results show that the scanner can produce medium-high quality images, with spatial resolution better than 2 mm in radiography, below 3 mm in tomography and resolving power in the RSP comparable to other state-of-the-art pCT scanners.

Abstract: Collapsing supermassive stars (M greater than or similar to 3 x 10(4) M-circle dot) at high redshifts can naturally provide seeds and explain the origin of the supermassive black holes observed in the centers of nearly all galaxies. During the collapse of supermassive stars, a burst of non-thermal neutrinos is generated with a luminosity that could greatly exceed that of a conventional core collapse supernova explosion. In this work, we investigate the extent to which the neutrinos produced in these explosions can be observed via coherent elastic neutrino-nucleus scattering (CEvNS). Large scale direct dark matter detection experiments provide particularly favorable targets. We find that upcoming O(100) tonne-scale experiments will be sensitive to the collapse of individual supermassive stars at distances as large as O(10) Mpc.

Abstract: One factor limiting the current applicability extent of hadron therapy is the lack of a reliable method for real time treatment monitoring. The use of Compton imaging systems as monitors requires the correct reconstruction of the distribution of prompt gamma productions during patient irradiation. In order to extract the maximum information from all the measurable events, we implemented a spectral reconstruction method that assigns to all events a probability of being either partial or total energy depositions. The method, implemented in a list-mode maximum likelihood expectation maximization algorithm, generates a four dimensional image in the joint spatial-spectral domain, in which the voxels containing the emission positions and energies are obtained. The analytical model used for the system response function is also employed to derive an analytical expression for the sensitivity, which is calculated via Monte Carlo integration. The performance of the method is evaluated through reconstruction of various experimental and simulated sources with different spatial and energy distributions. The results show that the proposed method can recover the spectral and spatial information simultaneously, but only under the assumption of ideal measurements. The analysis of the Monte Carlo simulations has led to the identification of two important degradation sources: the mispositioning of the gamma interaction point and the missing energy recorded in the interaction. Both factors are related to the high energy transferred to the recoil electrons, which can travel far from the interaction point and even escape the detector. These effects prevent the direct application of the current method in more realistic scenarios. Nevertheless, experimental point-like sources have been accurately reconstructed and the spatial distributions and spectral emission of complex simulated phantoms can be identified.

Abstract: The impact of dark matter-neutrino interactions on the measurement of the cosmological parameters has been investigated in the past in the context of massless neutrinos exclusively. Here we revisit the role of a neutrino-dark matter coupling in light of ongoing cosmological tensions by implementing the full Boltzmann hierarchy for three massive neutrinos. Our tightest 95% CL upper limit on the strength of the interactions, parameterized via u(chi) = sigma(0)/sigma(Th) (m(chi)/100GeV)(-1), is u(chi) <= 3.34 . 10(-4), arising from a combination of Planck TTTEEE data, Planck lensing data and SDSS BAO data. This upper bound is, as expected, slightly higher than previous results for interacting massless neutrinos, due to the correction factor associated with neutrino masses. We find that these interactions significantly relax the lower bounds on the value of sigma 8 that is inferred in the context of Lambda CDM from the Planck data, leading to agreement within 1-2 sigma with weak lensing estimates of sigma 8, as those from KiDS1000. However, the presence of these interactions barely affects the value of the Hubble constant H-0.

Abstract: We establish the possibility of Landau damping for gravitational scalar waves which propagate in a non-collisional gas of particles. In particular, under the hypothesis of homogeneity and isotropy, we describe the medium at the equilibrium with a Juttner-Maxwell distribution, and we analytically determine the damping rate from the Vlasov equation. We find that damping occurs only if the phase velocity of the wave is subluminal throughout the propagation within the medium. Finally, we investigate relativistic media in cosmological settings by adopting numerical techniques.