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Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
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Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
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Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
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Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
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Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
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Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
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Address  |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
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Mdpi |
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English |
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WOS:001269841000001 |
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no |
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yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6204 |
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Author |
Di Bari, P.; King, S.F.; Hossain Rahat, M. |
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Title |
Gravitational waves from phase transitions and cosmic strings in neutrino mass models with multiple majorons |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
05 |
Issue |
5 |
Pages |
068 - 31pp |
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Keywords |
Cosmology of Theories BSM; Early Universe Particle Physics; Phase Transitions in the Early Universe |
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Abstract |
We explore the origin of Majorana masses within the majoron model and how this can lead to the generation of a distinguishable primordial stochastic background of gravitational waves. We first show how in the simplest majoron model only a contribution from cosmic string can be within the reach of planned experiments. We then consider extensions containing multiple complex scalars, demonstrating how in this case a spectrum comprising contributions from both a strong first order phase transition and cosmic strings can naturally emerge. We show that the interplay between multiple scalar fields can amplify the phase transition signal, potentially leading to double peaks over the wideband sloped spectrum from cosmic strings. We also underscore the possibility of observing such a gravitational wave background to provide insights into the reheating temperature of the universe. We conclude highlighting how the model can be naturally combined with scenarios addressing the origin of matter of the universe, where baryogenesis occurs via leptogenesis and a right-handed neutrino plays the role of dark matter. |
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Address |
[Di Bari, Pasquale; King, Stephen F.; Rahat, Moinul Hossain] Univ Southampton, Sch Phys & Astron, Southampton SO17 1BJ, England, Email: P.Di-Bari@soton.ac.uk; |
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Springer |
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English |
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1029-8479 |
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WOS:001256020200004 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6182 |
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Author |
LHCb Collaboration (Aaij, R. et al); Jaimes Elles, S.J.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Rebollo De Miguel, M.; Sanderswood, I., Zhuo, J. |
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Title |
Amplitude Analysis of the B0 -> K*0 μ+μ- Decay |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
132 |
Issue |
13 |
Pages |
131801 - 13pp |
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Abstract |
An amplitude analysis of the B-0 -> K*(0) mu(+)mu(-) decay is presented using a dataset corresponding to an integrated luminosity of 4.7 fb(-1) of pp collision data collected with the LHCb experiment. For the first time, the coefficients associated to short-distance physics effects, sensitive to processes beyond the standard model, are extracted directly from the data through a q(2)-unbinned amplitude analysis, where q(2) is the mu(+)mu(-) invariant mass squared. Long-distance contributions, which originate from nonfactorizable QCD processes, are systematically investigated, and the most accurate assessment to date of their impact on the physical observables is obtained. The pattern of measured corrections to the short-distance couplings is found to be consistent with previous analyses of b- to s-quark transitions, with the largest discrepancy from the standard model predictions found to be at the level of 1.8 standard deviations. The global significance of the observed differences in the decay is 1.4 standard deviations. |
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Address |
[Dettori, F.; Fujii, Y.; Hadavizadeh, T.; Lane, J. J.; Litvinov, R.; Manca, G.; Saitta, B.; Ward, J. A.] Monash Univ, Sch Phys & Astron, Melbourne, Australia |
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Amer Physical Soc |
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English |
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ISSN |
0031-9007 |
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Notes |
WOS:001201992300011 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6127 |
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Author |
Delgado, R.L.; Gomez-Ambrosio, R.; Martinez-Martin, J.; Salas-Bernardez, A.; Sanz-Cillero, J.J. |
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Title |
Production of two, three, and four Higgs bosons: where SMEFT and HEFT depart |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
03 |
Issue |
3 |
Pages |
037 - 45pp |
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Keywords |
Anomalous Higgs Couplings; Higgs Properties; Strongly Interacting Higgs; Electroweak Precision Physics |
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Abstract |
In this article we study the phenomenological implications of multiple Higgs boson production from longitudinal vector boson scattering in the context of effective field theories. We find compact representations for effective tree-level amplitudes with up to four final state Higgs bosons. Total cross sections are then computed for scenarios relevant at the LHC in which we find the general Higgs Effective Theory (HEFT) prediction avoids the heavy suppression observed in Standard Model Effective Field Theory (SMEFT). |
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Address |
[Delgado, Rafael L.] Univ Politecn Madrid, Dept Matemat Aplicadas TIC, Nikola Tesla,s-n, Madrid 28031, Spain, Email: rafael.delgado@upm.es; |
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Springer |
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English |
Summary Language |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1029-8479 |
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Conference |
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Notes |
WOS:001177947600003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6013 |
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Author |
del Rio, A.; Ester, E.A. |
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Title |
Electrically charged black hole solutions in semiclassical gravity and dynamics of linear perturbations |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
109 |
Issue |
10 |
Pages |
105022 - 23pp |
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Abstract |
We explore quantum corrections of electrically charged black holes subject to vacuum polarization effects of fermion fields in QED. Solving this problem exactly is challenging so we restrict to perturbative corrections that one can obtain using the heat kernel expansion in the one -loop effective action for electrons. Starting from the corrections originally computed by Drummond and Hathrell, we solve the full semiclassical Einstein -Maxwell system of coupled equations to leading order in Planck 's constant and find a new electrically charged, static black hole solution. To probe these quantum corrections, we study electromagnetic and gravitational (axial) perturbations on this background and derive the coupled system of Regge-Wheeler master equations that govern the propagation of these waves. In the classical limit, our results agree with previous findings in the literature. We finally compare these results with those that one can obtain by working out the Euler-Heisenberg effective action. We find again a new electrically charged static black hole spacetime and derive the coupled system of Regge-Wheeler equations governing the propagation of axial electromagnetic and gravitational perturbations. Results are qualitatively similar in both cases. We briefly discuss some challenges found in the numerical computation of the quasinormal mode frequency spectra when quantum corrections are included. |
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Address |
[del Rio, Adrian] Univ Valencia, Dept Fis Teor, CSIC, Dr Moliner 50, Burjassot 46100, Valencia, Spain, Email: adrian.rio@uv.es; |
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Amer Physical Soc |
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English |
Summary Language |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2470-0010 |
ISBN |
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Expedition |
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Conference |
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Notes |
WOS:001239211500007 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6151 |
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Author |
Andreotti, M. et al; Cervera-Villanueva, A.; Garcia-Peris, M. a.; Martin-Albo, J.; Querol, M.; Rocabado, J.; Saadana, A. |
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Title |
Cryogenic characterization of Hamamatsu HWB MPPCs for the DUNE photon detection system |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
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Volume |
19 |
Issue |
1 |
Pages |
T01007 - 27pp |
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Keywords |
Cryogenic detectors; Photon detectors for UV, visible and IR photons (solid-state); Photon detectors for UV, visible and IR photons (solid-state) (PIN diodes, APDs, Si-PMTs, G-APDs, CCDs, EBCCDs, EMCCDs, CMOS imagers, etc) |
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Abstract |
The Deep Underground Neutrino Experiment (DUNE) is a next generation experiment aimed to study neutrino oscillation. Its long-baseline configuration will exploit a Near Detector (ND) and a Far Detector (FD) located at a distance of similar to 1300 km. The FD will consist of four Liquid Argon Time Projection Chamber (LAr TPC) modules. A Photon Detection System (PDS) will be used to detect the scintillation light produced inside the detector after neutrino interactions. The PDS will be based on light collectors coupled to Silicon Photomultipliers (SiPMs). Different photosensor technologies have been proposed and produced in order to identify the best samples to fullfill the experiment requirements. In this paper, we present the procedure and results of a validation campaign for the Hole Wire Bonding (HWB) MPPCs samples produced by Hamamatsu Photonics K.K. (HPK) for the DUNE experiment, referring to them as 'SiPMs'. The protocol for a characterization at cryogenic temperature (77 K) is reported. We present the down-selection criteria and the results obtained during the selection campaign undertaken, along with a study of the main sources of noise of the SiPMs including the investigation of a newly observed phenomenon in this field. |
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Address |
[de Souza, H. Vieira] Univ Paris Cite, Lab Astroparticule & Cosmol, APC, Paris, France, Email: elisabetta.montagna@bo.infn.it |
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Publisher |
IOP Publishing Ltd |
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English |
Summary Language |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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ISSN |
1748-0221 |
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Notes |
WOS:001178134800001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6072 |
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Author |
LHCb Collaboration (Aaij, R. et al); Jaimes Elles, S.J.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Rebollo De Miguel, M.; Ruiz Vidal, J.; Sanderswood, I.; Zhuo, J. |
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Title |
Measurement of prompt D+ and Ds+ production in pPb collisions at √s_NN=5.02 TeV |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
01 |
Issue |
1 |
Pages |
070 - 43pp |
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Keywords |
Heavy Quark Production; Relativistic Heavy Ion Physics; QCD; Heavy Ion Experiments |
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Abstract |
The production of prompt D+ and D-s(+) mesons is studied in proton-lead collisions at a centre-of-mass energy of root s(NN) = 5.02TeV. The data sample corresponding to an integrated luminosity of (1.58 +/- 0.02)nb(-1) is collected by the LHCb experiment at the LHC. The differential production cross-sections are measured using D+ and D-s(+) candidates with transverse momentum in the range of 0 < p(T) < 14 GeV/c and rapidities in the ranges of 1.5 < y* < 4.0 and -5.0 < y* < -2.5 in the nucleon-nucleon centre-of-mass system. For both particles, the nuclear modification factor and the forward-backward production ratio are determined. These results are compared with theoretical models that include initial-state nuclear effects. In addition, measurements of the cross-section ratios between D+, D-s(+) and D-0 mesons are presented, providing a baseline for studying the charm hadronization in lead-lead collisions at LHC energies. |
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Address |
[de Souza Leite, J. Baptista; Bediaga, I. B.; Torres, M. Cruz; Carneiro Da Graca, U. De Freitas; De Miranda, J. M.; dos Reis, A. C.; Falcao, L. N.; Gomes, A.; Massaferri, A.; Santoro, L.; Machado, D. Torres] Ctr Brasileiro Pesquisas Fis CBPF, Rio De Janeiro, Brazil, Email: yiheng.luo@cern.ch |
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Publisher |
Springer |
Place of Publication |
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Language |
English |
Summary Language |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1029-8479 |
ISBN |
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Expedition |
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Conference |
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Notes |
WOS:001190227500001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6021 |
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Author |
De Romeri, V.; Papoulias, D.K.; Ternes, C.A. |
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Title |
Light vector mediators at direct detection experiments |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
05 |
Issue |
5 |
Pages |
165 - 22pp |
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Keywords |
New Gauge Interactions; New Light Particles; Specific BSM Phenomenology |
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Abstract |
Solar neutrinos induce elastic neutrino-electron scattering in dark matter direct detection experiments, resulting in detectable event rates at current facilities. We analyze recent data from the XENONnT, LUX-ZEPLIN, and PandaX-4T experiments and we derive stringent constraints on several U(1) ' extensions of the Standard Model, accommodating new neutrino-electron interactions. We provide bounds on the relevant coupling and mass of light vector mediators for a variety of models, including the anomaly-free B – L model, lepton flavor-dependent interactions like L alpha – L beta , B – 2L e – L mu,tau , B – 3L alpha , and B + 2L μ+ 2L tau models. We compare our results with other limits obtained in the literature from both terrestrial and astrophysical experiments. Finally, we present forecasts for improving current bounds with a future experiment like DARWIN. |
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Address |
[De Romeri, Valentina] Univ Valencia, Inst Fis Corpuscular, CSIC, Parc Cient UV C Catedrat Jose Beltran 2, E-46980 Paterna, Valencia, Spain, Email: deromeri@ific.uv.es; |
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Publisher |
Springer |
Place of Publication |
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Language |
English |
Summary Language |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1029-8479 |
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Notes |
WOS:001224185000004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6132 |
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Author |
De Romeri, V.; Martin Lozano, V.; Sanchez Garcia, G. |
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Title |
Neutrino window to scalar leptoquarks: From low energy to colliders |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
109 |
Issue |
5 |
Pages |
055014 - 21pp |
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Keywords |
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Abstract |
Leptoquarks are theorized particles of either scalar or vector nature that couple simultaneously to quarks and leptons. Motivated by recent measurements of coherent elastic neutrino -nucleus scattering, we consider the impact of scalar leptoquarks coupling to neutrinos on a few complementary processes, from low energy to colliders. In particular, we set competitive constraints on the typical mass and coupling of scalar leptoquarks by analyzing recent COHERENT data. We compare these constraints with bounds from atomic parity violation experiments, deep inelastic neutrino -nucleon scattering and collider data. Our results highlight a strong complementarity between different facilities and demonstrate the power of coherent elastic neutrino -nucleus scattering experiments to probe leptoquark masses in the sub-TeV range. Finally, we also present prospects for improving current bounds with future upgrades of the COHERENT detectors and the planned European Spallation Source. |
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Address |
[De Romeri, Valentina; Lozano, Victor Martin; Garcia, G. Sanchez] Univ Valencia, CSIC, Inst Fis Corpuscular, Parc Cient UV C Catedrat Jose Beltran 2, E-46980 Valencia, Spain, Email: deromeri@ific.uv.es; |
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Publisher |
Amer Physical Soc |
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English |
Summary Language |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2470-0010 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001195802100003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6039 |
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Author |
Das, B. et al; Algora, A. |
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Title |
Broken seniority symmetry in the semimagic proton mid-shell nucleus 95Rh |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review Research |
Abbreviated Journal |
Phys. Rev. Res. |
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Volume |
6 |
Issue |
2 |
Pages |
L022038 - 7pp |
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Keywords |
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Abstract |
Lifetime measurements of low-lying excited states in the semimagic ( N = 50) nucleus 95 Rh have been performed by means of the fast -timing technique. The experiment was carried out using gamma -ray detector arrays consisting of LaBr 3 (Ce) scintillators and germanium detectors integrated into the DESPEC experimental setup commissioned for the Facility for Antiproton and Ion Research ( FAIR ) Phase -0, Darmstadt, Germany. The excited states in 95 Rh were populated primarily via the /3 decays of 95 Pd nuclei, produced in the projectile fragmentation of a 850 MeV / nucleon 124 Xe beam impinging on a 4 g / cm 2 9 Be target. The deduced electromagnetic E2 transition strengths for the gamma -ray cascade within the multiplet structure depopulating from the isomeric I pi = 21 / 2 + state are found to exhibit strong deviations from predictions of standard shell model calculations which feature approximately conserved seniority symmetry. In particular, the observation of a strongly suppressed E2 strength for the 13 / 2 + -> 9 / 2 + ground state transition cannot be explained by calculations employing standard interactions. This remarkable result may require revision of the nucleon-nucleon interactions employed in state-of-the-art theoretical model calculations, and might also point to the need for including three-body forces in the Hamiltonian. |
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Address |
[Das, B.; Cederwall, B.; Qi, C.; Aktas, O.; Liotta, R.; Vasiljevic, J.] KTH Royal Inst Technol, S-10691 Stockholm, Sweden, Email: b.das@gsi.de; |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
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ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001240855200002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6147 |
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