Abstract: Objective. The Jagiellonian positron emission tomography (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach. Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualized in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results. Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r (2) = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance. The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment.

Abstract: The search for neutrinoless double beta decay (0νββ) remains one of the most compelling experimental avenues for the discovery in the neutrino sector. Electroluminescent gas-phase time projection chambers are well suited to 0νββ searches due to their intrinsically precise energy resolution and topological event identification capabilities. Scalability to ton-and multi-ton masses requires readout of large-area electroluminescent regions with fine spatial resolution, low radiogenic backgrounds, and a scalable data acquisition system. This paper presents a detector prototype that records event topology in an electroluminescent xenon gas TPC via VUV image-intensified cameras. This enables an extendable readout of large tracking planes with commercial devices that reside almost entirely outside of the active medium. Following further development in intermediate scale demonstrators, this technique may represent a novel and enlargeable method for topological event imaging in 0νββ.

Abstract: Ring dosimeters for personal dosimetry are calibrated in accredited laboratories following ISO 4037-3 guidelines. The simultaneous irradiation of multiple dosimeters would save time, but has to be carefully studied, since the scattering conditions could change and influence the absorbed dose in nearby dosimeters. Monte Carlo simulations using PENELOPE-2014 were performed to explore the need to increase the uncertainty of H-p (0.07) in the simultaneous irradiation of three and five DXT-RAD 707H-2 (Thermo Scientific) ring dosimeters with beam qualities: N-30, N-80 and N-300. Results show that the absorbed dose in each dosimeter is compatible with each of the others and with the reference simulation (a single dosimeter), with a coverage probability of 95% (k = 2). Comparison with experimental data yielded consistent results with the same coverage probability. Therefore, five ring dosimeters can be simultaneously irradiated with beam qualities ranging, at least, between N-30 and N-300 with a negligible impact on the uncertainty of H-p (0.07).

Abstract: The stringent experimental bound on μ-> e gamma is compatible with a simultaneous and sizable new physics contribution to the electron and muon anomalous magnetic moments (g – 2)(l) (l = e, mu), only if we assume a non-trivial flavor structure of the dipole operator coefficients. We propose a mechanism in which the realization of the (g – 2)(l) correction is manifestly related to the mass generation through a flavor symmetry. A radiative flavon correction to the fermion mass gives a contribution to the anomalous magnetic moment. In this framework, we introduce a chiral enhancement from a non-trivial O(1) quartic coupling of the scalar potential. We show that the muon and electron anomalies can be simultaneously explained in a vast region of the parameter space with predicted vector-like mediators of masses as large as M chi is an element of [0.6, 2.5] TeV.

Abstract: We propose a novel realization of the Nelson-Barr mechanism “seeded” by a dark sector containing scalars and vectorlike quarks. Charge parity (CP) and a Z8 symmetry are spontaneously broken by the complex vacuum expectation value of a singlet scalar, leaving a residual Z2 symmetry that stabilizes dark matter (DM). A complex Cabibbo-Kobayashi-Maskawa matrix arises via one-loop corrections to the quark mass matrix mediated by the dark sector. In contrast with other proposals where nonzero contributions to the strong CP phase arise at the one-loop level, in our case this occurs only at two loops, enhancing naturalness. Our scenario also provides a viable weakly interacting massive particle scalar DM candidate.