Abstract: The CPT symmetry, which combines Charge Conjugation, Parity, and Time Reversal, is a cornerstone of our model-building method, and its probable violation will endanger the most extended tool we presently utilize to explain physics, namely local relativistic quantum fields. However, the kaon system's conservation constraints appear to be rather severe. We will show in this paper that neutrino oscillation experiments can enhance this limit by many orders of magnitude, making them an excellent instrument for investigating the basis of our understanding of Nature. As a result, verifying CPT invariance does not evaluate a specific model, but rather the entire paradigm. Therefore, as the CPT's status in the neutrino sector, linked or not to Lorentz invariance violation, will be assessed at an unprecedented level by current and future long baseline experiments, distinguishing it from comparable experimental fingerprints coming from non-standard interactions is critical. Whether the entire paradigm or simply the conventional model of neutrinos is at jeopardy is significantly dependent on this.

Abstract: Constraints on inflationary models typically assume only the standard models of cosmology and particle physics. By extending the neutrino sector to include a new interaction with a light scalar mediator (m(phi) similar to MeV), it is possible to relax these constraints, in particular via opening up regions of the parameter space of the spectral index n(s). These new interactions can be probed at IceCube via interactions of astrophysical neutrinos with the cosmic neutrino background for nearly all of the relevant parameter space.

Abstract: The evolution of the universe prior to Big Bang Nucleosynthesis could have gone through a phase of early matter domination which enhanced the growth of small-scale dark matter structure. If this period was long enough, self-gravitating objects formed prior to reheating. We study the evolution of these dense early halos through reheating. At the end of early matter domination, the early halos undergo rapid expansion and eventually eject their matter. We find that this process washes out structure on scales much larger than naively expected from the size of the original halos. We compute the density profiles of the early halo remnants and use them to construct late-time power spectra that include these non-linear effects. We evolve the resulting power spectrum to estimate the properties of microhalos that would form after matter-radiation equality. Surprisingly, cosmologies with a short period of early matter domination lead to an earlier onset of microhalo formation compared to those with a long period. In either case, dark matter structure formation begins much earlier than in the standard cosmology, with most dark matter bound in microhalos in the late universe.

Abstract: Hadron therapy is a radiotherapy modality which offers a precise energy deposition to the tumors and a dose reduction to healthy tissue as compared to conventional methods. However, methods for real-time monitoring are required to ensure that the radiation dose is deposited on the target. The IRIS group of IFIC-Valencia developed a Compton camera prototype for this purpose, intending to image the Prompt Gammas emitted by the tissue during irradiation. The system detectors are composed of Lanthanum (III) bromide scintillator crystals coupled to silicon photomultipliers. After an initial characterization in the laboratory, in order to assess the system capabilities for future experiments in proton therapy centers, different tests were carried out in two facilities: PARTREC (Groningen, The Netherlands) and the CNA cyclotron (Sevilla, Spain). Characterization studies performed at PARTREC indicated that the detectors linearity was improved with respect to the previous version and an energy resolution of 5.2 % FWHM at 511 keV was achieved. Moreover, the imaging capabilities of the system were evaluated with a line source of 68Ge and a point-like source of 241Am-9Be. Images at 4.439 MeV were obtained from irradiation of a graphite target with an 18 MeV proton beam at CNA, to perform a study of the system potential to detect shifts at different intensities. In this sense, the system was able to distinguish 1 mm variations in the target position at different beam current intensities for measurement times of 1800 and 600 s.

Abstract: The IRIS group at IFIC-Valencia has developed a second version of a Compton camera prototype for hadron therapy treatment monitoring, with the aim of improving the performance with respect to its predecessor. The system is composed of three Lanthanum (III) bromide (LaBr3) crystals coupled to silicon photomultipliers (SiPMs). The detector energy resolution has been improved to 5.6% FWHM at 511 keV and an angular resolution of 8.0 degrees has been obtained. Images of a Na-22 point-like source have been reconstructed selecting two and three interaction events. Moreover, the experimental data have been reproduced with Monte Carlo simulations using a Compton camera module (CCMod) in GATE v8.2 obtaining a good correlation.