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Nadal-Gisbert, S., Navarro-Salas, J., & Pla, S. (2023). Low-energy states and CPT invariance at the big bang. Phys. Rev. D, 107(8), 085018–16pp.
Abstract: In this paper, we analyze the quantum vacuum in a radiation-dominated and CPT -invariant universe by further imposing the quantum states to be ultraviolet regular i.e., satisfying the Hadamard/adiabatic condition. For scalar fields, this is enforced by constructing the vacuum via the states of low-energy proposal. For spin -12 fields, we extend this proposal for a FLRW spacetime and apply it for the radiation-dominated and CPT -invariant universe. We focus on minimizing the smeared energy density around the big bang and give strong evidence that the resulting states satisfy the Hadamard/adiabatic condition. These states are then self -consistent candidates as effective big bang quantum vacuum from the field theory perspective.
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Nada, A., & Ramos, A. (2021). An analysis of systematic effects in finite size scaling studies using the gradient flow. Eur. Phys. J. C, 81(1), 1–19pp.
Abstract: We propose a new strategy for the determination of the step scaling function sigma (u) in finite size scaling studies using the gradient flow. In this approach the determination of sigma (u) is broken in two pieces: a change of the flow time at fixed physical size, and a change of the size of the system at fixed flow time. Using both perturbative arguments and a set of simulations in the pure gauge theory we show that this approach leads to a better control over the continuum extrapolations. Following this new proposal we determine the running coupling at high energies in the pure gauge theory and re-examine the determination of the Lambda -parameter, with special care on the perturbative truncation uncertainties.
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Nacher, E., Briz, J. A., Nerio, A. N., Perea, A., Tavora, V. G., Tengblad, O., et al. (2024). Characterization of a novel proton-CT scanner based on Silicon and LaBr3(Ce) detectors. Eur. Phys. J. Plus, 139(5), 404–9pp.
Abstract: Treatment planning systems at proton-therapy centres entirely use X-ray computed tomography (CT) as primary imaging technique to infer the proton treatment doses to tumour and healthy tissues. However, proton stopping powers in the body, as derived from X-ray images, suffer from important proton-range uncertainties. In order to reduce this uncertainty in range, one could use proton-CT images instead. The main goal of this work is to test the capabilities of a newly-developed proton-CT scanner, based on the use of a set of tracking detectors and a high energy resolution scintillator for the residual energy of the protons. Different custom-made phantoms were positioned at the field of view of the scanner and were irradiated with protons at the CCB proton-therapy center in Krakow. We measured with the phantoms at different angles and produced sinograms that were used to obtain reconstructed images by Filtered Back-Projection. The obtained images were used to determine the capabilities of our scanner in terms of spatial resolution and proton Relative Stopping Power (RSP) mapping and validate its use as proton-CT scanner. The results show that the scanner can produce medium-high quality images, with spatial resolution better than 2 mm in radiography, below 3 mm in tomography and resolving power in the RSP comparable to other state-of-the-art pCT scanners.
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Murgui, C., Peñuelas, A., Jung, M., & Pich, A. (2019). Global fit to b -> c tau nu transitions. J. High Energy Phys., 09(9), 103–45pp.
Abstract: We perform a general model-independent analysis of b -> c tau(nu) over bar (tau) transitions, including measurements of R-D, R-D*, their q(2) differential distributions, the recently measured longitudinal D* polarization F-L(D)*, and constraints from the B-c -> tau(nu) over bar (tau) lifetime, each of which has significant impact on the fit. A global fit to a general set of Wilson coefficients of an effective low-energy Hamiltonian is presented, the solutions of which are interpreted in terms of hypothetical new-physics mediators. From the obtained results we predict selected b -> c tau(nu) over bar (tau) observables, such as the baryonic transition Lambda(b) -> Lambda(c)tau(nu) over bar (tau), the ratio R-J/psi, the forward-backward asymmetries A(FB)(D()*()), the tau polarization asymmetries P-tau(D()*()), and the longitudinal D* polarization fraction F-L(D)*. The latter shows presently a slight tension with any new-physics model, such that an improved measurement could have an important impact. We also discuss the potential change due the very recently announced preliminary R-D(*) measurement by the Belle collaboration.
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Muñoz, V., Takhistov, V., Witte, S. J., & Fuller, G. M. (2021). Exploring the origin of supermassive black holes with coherent neutrino scattering. J. Cosmol. Astropart. Phys., 11(11), 020–16pp.
Abstract: Collapsing supermassive stars (M greater than or similar to 3 x 10(4) M-circle dot) at high redshifts can naturally provide seeds and explain the origin of the supermassive black holes observed in the centers of nearly all galaxies. During the collapse of supermassive stars, a burst of non-thermal neutrinos is generated with a luminosity that could greatly exceed that of a conventional core collapse supernova explosion. In this work, we investigate the extent to which the neutrinos produced in these explosions can be observed via coherent elastic neutrino-nucleus scattering (CEvNS). Large scale direct dark matter detection experiments provide particularly favorable targets. We find that upcoming O(100) tonne-scale experiments will be sensitive to the collapse of individual supermassive stars at distances as large as O(10) Mpc.
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Muñoz, E., Ros, A., Borja-Lloret, M., Barrio, J., Dendooven, P., Oliver, J. F., et al. (2021). Proton range verification with MACACO II Compton camera enhanced by a neural network for event selection. Sci Rep, 11(1), 9325–12pp.
Abstract: The applicability extent of hadron therapy for tumor treatment is currently limited by the lack of reliable online monitoring techniques. An active topic of investigation is the research of monitoring systems based on the detection of secondary radiation produced during treatment. MACACO, a multi-layer Compton camera based on LaBr3 scintillator crystals and SiPMs, is being developed at IFIC-Valencia for this purpose. This work reports the results obtained from measurements of a 150 MeV proton beam impinging on a PMMA target. A neural network trained on Monte Carlo simulations is used for event selection, increasing the signal to background ratio before image reconstruction. Images of the measured prompt gamma distributions are reconstructed by means of a spectral reconstruction code, through which the 4.439 MeV spectral line is resolved. Images of the emission distribution at this energy are reconstructed, allowing calculation of the distal fall-off and identification of target displacements of 3 mm.
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Muñoz, E., Barrio, J., Etxebeste, A., Ortega, P. G., Lacasta, C., Oliver, J. F., et al. (2017). Performance evaluation of MACACO: a multilayer Compton camera. Phys. Med. Biol., 62(18), 7321–7341.
Abstract: Compton imaging devices have been proposed and studied for a wide range of applications. We have developed a Compton camera prototype which can be operated with two or three detector layers based on monolithic lanthanum bromide (LaBr3) crystals coupled to silicon photomultipliers (SiPMs), to be used for proton range verification in hadron therapy. In this work, we present the results obtained with our prototype in laboratory tests with radioactive sources and in simulation studies. Images of a Na-22 and an Y-88 radioactive sources have been successfully reconstructed. The full width half maximum of the reconstructed images is below 4 mm for a Na-22 source at a distance of 5 cm.
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Muñoz, E., Barrio, J., Bernabeu, J., Etxebeste, A., Lacasta, C., Llosa, G., et al. (2018). Study and comparison of different sensitivity models for a two-plane Compton camera. Phys. Med. Biol., 63(13), 135004–19pp.
Abstract: Given the strong variations in the sensitivity of Compton cameras for the detection of events originating from different points in the field of view (FoV), sensitivity correction is often necessary in Compton image reconstruction. Several approaches for the calculation of the sensitivity matrix have been proposed in the literature. While most of these models are easily implemented and can be useful in many cases, they usually assume high angular coverage over the scattered photon, which is not the case for our prototype. In this work, we have derived an analytical model that allows us to calculate a detailed sensitivity matrix, which has been compared to other sensitivity models in the literature. Specifically, the proposed model describes the probability of measuring a useful event in a two-plane Compton camera, including the most relevant physical processes involved. The model has been used to obtain an expression for the system and sensitivity matrices for iterative image reconstruction. These matrices have been validated taking Monte Carlo simulations as a reference. In order to study the impact of the sensitivity, images reconstructed with our sensitivity model and with other models have been compared. Images have been reconstructed from several simulated sources, including point-like sources and extended distributions of activity, and also from experimental data measured with Na-22 sources. Results show that our sensitivity model is the best suited for our prototype. Although other models in the literature perform successfully in many scenarios, they are not applicable in all the geometrical configurations of interest for our system. In general, our model allows to effectively recover the intensity of point-like sources at different positions in the FoV and to reconstruct regions of homogeneous activity with minimal variance. Moreover, it can be employed for all Compton camera configurations, including those with low angular coverage over the scatterer.
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Muñoz, E., Barrientos, L., Bernabeu, J., Borja-Lloret, M., Llosa, G., Ros, A., et al. (2020). A spectral reconstruction algorithm for two-plane Compton cameras. Phys. Med. Biol., 65(2), 025011–17pp.
Abstract: One factor limiting the current applicability extent of hadron therapy is the lack of a reliable method for real time treatment monitoring. The use of Compton imaging systems as monitors requires the correct reconstruction of the distribution of prompt gamma productions during patient irradiation. In order to extract the maximum information from all the measurable events, we implemented a spectral reconstruction method that assigns to all events a probability of being either partial or total energy depositions. The method, implemented in a list-mode maximum likelihood expectation maximization algorithm, generates a four dimensional image in the joint spatial-spectral domain, in which the voxels containing the emission positions and energies are obtained. The analytical model used for the system response function is also employed to derive an analytical expression for the sensitivity, which is calculated via Monte Carlo integration. The performance of the method is evaluated through reconstruction of various experimental and simulated sources with different spatial and energy distributions. The results show that the proposed method can recover the spectral and spatial information simultaneously, but only under the assumption of ideal measurements. The analysis of the Monte Carlo simulations has led to the identification of two important degradation sources: the mispositioning of the gamma interaction point and the missing energy recorded in the interaction. Both factors are related to the high energy transferred to the recoil electrons, which can travel far from the interaction point and even escape the detector. These effects prevent the direct application of the current method in more realistic scenarios. Nevertheless, experimental point-like sources have been accurately reconstructed and the spatial distributions and spectral emission of complex simulated phantoms can be identified.
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Muñoz, E., Barrio, J., Bemmerer, D., Etxebeste, A., Fiedler, F., Hueso-Gonzalez, F., et al. (2018). Tests of MACACO Compton telescope with 4.44 MeV gamma rays. J. Instrum., 13, P05007–13pp.
Abstract: Hadron therapy offers the possibility of delivering a large amount of radiation dose to tumors with minimal absorption by the surrounding healthy tissue. In order to fully exploit the advantages of this technique, the use of real-time beam monitoring devices becomes mandatory. Compton imaging devices can be employed to map the distribution of prompt gamma emission during the treatment and thus assess its correct delivery. The Compton telescope prototype developed at IFIC-Valencia for this purpose is made of three layers of LaBr3 crystals coupled to silicon photomultipliers. The system has been tested in a 4.44 MeV gamma field at the 3 MV Tandetron accelerator at HZDR, Dresden. Images of the target with the system in three different positions separated by 10 mm were successfully reconstructed. This indicates the ability of MACACO for imaging the prompt gamma rays emitted at such energies.
Keywords: Compton imaging; Instrumentation for hadron therapy; Gamma detectors (scintillators, CZT, HPG, HgI etc); Photon detectors for UV, visible and IR photons (solid state) (PIN diodes, APDs, Si PMTs, G APDs, CCDs, EBCCDs, EMCCDs etc)
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