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Albiol, A., Corbi, A., & Albiol, F. (2017). Automatic intensity windowing of mammographic images based on a perceptual metric. Med. Phys., 44(4), 1369–1378.
Abstract: Purpose: Initial auto-adjustment of the window level WL and width WW applied to mammographic images. The proposed intensity windowing (IW) method is based on the maximization of the mutual information (MI) between a perceptual decomposition of the original 12-bit sources and their screen displayed 8-bit version. Besides zoom, color inversion and panning operations, IW is the most commonly performed task in daily screening and has a direct impact on diagnosis and the time involved in the process. Methods: The authors present a human visual system and perception-based algorithm named GRAIL (Gabor-relying adjustment of image levels). GRAIL initially measures a mammogram's quality based on the MI between the original instance and its Gabor-filtered derivations. From this point on, the algorithm performs an automatic intensity windowing process that outputs the WL/WW that best displays each mammogram for screening. GRAIL starts with the default, high contrast, wide dynamic range 12-bit data, and then maximizes the graphical information presented in ordinary 8-bit displays. Tests have been carried out with several mammogram databases. They comprise correlations and an ANOVA analysis with the manual IW levels established by a group of radiologists. A complete MATLAB implementation of GRAIL is available at . Results: Auto-leveled images show superior quality both perceptually and objectively compared to their full intensity range and compared to the application of other common methods like global contrast stretching (GCS). The correlations between the human determined intensity values and the ones estimated by our method surpass that of GCS. The ANOVA analysis with the upper intensity thresholds also reveals a similar outcome. GRAIL has also proven to specially perform better with images that contain micro-calcifications and/or foreign X-ray-opaque elements and with healthy BI-RADS A-type mammograms. It can also speed up the initial screening time by a mean of 4.5 s per image. Conclusions: A novel methodology is introduced that enables a quality-driven balancing of the WL/WW of mammographic images. This correction seeks the representation that maximizes the amount of graphical information contained in each image. The presented technique can contribute to the diagnosis and the overall efficiency of the breast screening session by suggesting, at the beginning, an optimal and customized windowing setting for each mammogram.
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Albiol, F., Corbi, A., & Albiol, A. (2017). 3D measurements in conventional X-ray imaging with RGB-D sensors. Med. Eng. Phys., 42, 73–79.
Abstract: A method for deriving 3D internal information in conventional X-ray settings is presented. It is based on the combination of a pair of radiographs from a patient and it avoids the use of X-ray-opaque fiducials and external reference structures. To achieve this goal, we augment an ordinary X-ray device with a consumer RGB-D camera. The patient' s rotation around the craniocaudal axis is tracked relative to this camera thanks to the depth information provided and the application of a modern surface-mapping algorithm. The measured spatial information is then translated to the reference frame of the X-ray imaging system. By using the intrinsic parameters of the diagnostic equipment, epipolar geometry, and X-ray images of the patient at different angles, 3D internal positions can be obtained. Both the RGB-D and Xray instruments are first geometrically calibrated to find their joint spatial transformation. The proposed method is applied to three rotating phantoms. The first two consist of an anthropomorphic head and a torso, which are filled with spherical lead bearings at precise locations. The third one is made of simple foam and has metal needles of several known lengths embedded in it. The results show that it is possible to resolve anatomical positions and lengths with a millimetric level of precision. With the proposed approach, internal 3D reconstructed coordinates and distances can be provided to the physician. It also contributes to reducing the invasiveness of ordinary X-ray environments and can replace other types of clinical explorations that are mainly aimed at measuring or geometrically relating elements that are present inside the patient's body.
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Albiol, F., Corbi, A., & Albiol, A. (2017). Evaluation of modern camera calibration techniques for conventional diagnostic X-ray imaging settings. Radiol. Phys. Technol., 10(1), 68–81.
Abstract: We explore three different alternatives for obtaining intrinsic and extrinsic parameters in conventional diagnostic X-ray frameworks: the direct linear transform (DLT), the Zhang method, and the Tsai approach. We analyze and describe the computational, operational, and mathematical background differences for these algorithms when they are applied to ordinary radiograph acquisition. For our study, we developed an initial 3D calibration frame with tin cross-shaped fiducials at specific locations. The three studied methods enable the derivation of projection matrices from 3D to 2D point correlations. We propose a set of metrics to compare the efficiency of each technique. One of these metrics consists of the calculation of the detector pixel density, which can be also included as part of the quality control sequence in general X-ray settings. The results show a clear superiority of the DLT approach, both in accuracy and operational suitability. We paid special attention to the Zhang calibration method. Although this technique has been extensively implemented in the field of computer vision, it has rarely been tested in depth in common radiograph production scenarios. Zhang's approach can operate on much simpler and more affordable 2D calibration frames, which were also tested in our research. We experimentally confirm that even three or four plane-image correspondences achieve accurate focal lengths.
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Alcaide, J., Salvado, J., & Santamaria, A. (2018). Fitting flavour symmetries: the case of two-zero neutrino mass textures. J. High Energy Phys., 07(7), 164–18pp.
Abstract: We present a numeric method for the analysis of the fermion mass matrices predicted in flavour models. The method does not require any previous algebraic work, it offers a chi(2) comparison test and an easy estimate of confidence intervals. It can also be used to study the stability of the results when the predictions are disturbed by small perturbations. We have applied the method to the case of two-zero neutrino mass textures using the latest available fits on neutrino oscillations, derived the available parameter space for each texture and compared them. Textures A(1) and A(2) seem favoured because they give a small chi(2), allow for large regions in parameter space and give neutrino masses compatible with Cosmology limits. The other “allowed” textures remain allowed although with a very constrained parameter space, which, in some cases, could be in conflict with Cosmology. We have also revisited the “forbidden” textures and studied the stability of the results when the texture zeroes are not exact. Most of the forbidden textures remain forbidden, but textures F-1 and F-3 are particularly sensitive to small perturbations and could become allowed.
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Alcaide, J., Banerjee, S., Chala, M., & Titov, A. (2019). Probes of the Standard Model effective field theory extended with a right-handed neutrino. J. High Energy Phys., 08(8), 031–18pp.
Abstract: If neutrinos are Dirac particles and, as suggested by the so far null LHC results, any new physics lies at energies well above the electroweak scale, the Standard Model effective field theory has to be extended with operators involving the right-handed neutrinos. In this paper, we study this effective field theory and set constraints on the different dimension-six interactions. To that aim, we use LHC searches for associated production of light (and tau) leptons with missing energy, monojet searches, as well as pion and tau decays. Our bounds are generally above the TeV for order one couplings. One particular exception is given by operators involving top quarks. These provide new signals in top decays not yet studied at colliders. Thus, we also design an LHC analysis to explore these signatures in the tt production. Our results are also valid if the right-handed neutrinos are Majorana and long-lived.
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Alcaide, J., Das, D., & Santamaria, A. (2017). A model of neutrino mass and dark matter with large neutrinoless double beta decay. J. High Energy Phys., 04(4), 049–21pp.
Abstract: We propose a model where neutrino masses are generated at three loop order but neutrinoless double beta decay occurs at one loop. Thus we can have large neutrinoless double beta decay observable in the future experiments even when the neutrino masses are very small. The model receives strong constraints from the neutrino data and lepton flavor violating decays, which substantially reduces the number of free parameters. Our model also opens up the possibility of having several new scalars below the TeV regime, which can be explored at the collider experiments. Additionally, our model also has an unbroken Z(2) symmetry which allows us to identify a viable Dark Matter candidate.
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n_TOF Collaboration(Alcayne, V. et al), Balibrea-Correa, J., Domingo-Pardo, C., Lerendegui-Marco, J., Babiano-Suarez, V., & Ladarescu, I. (2024). A Segmented Total Energy Detector (sTED) optimized for (n,γ) cross-section measurements at n_TOF EAR2. Radiat. Phys. Chem., 217, 11pp.
Abstract: The neutron time-of-flight facility nTOF at CERN is a spallation source dedicated to measurements of neutroninduced reaction cross-sections of interest in nuclear technologies, astrophysics, and other applications. Since 2014, Experimental ARea 2 (EAR2) is operational and delivers a neutron fluence of similar to 4 center dot 10(7) neutrons per nominal proton pulse, which is similar to 50 times higher than the one of Experimental ARea 1 (EAR1) of similar to 8 center dot 10(5) neutrons per pulse. The high neutron flux at EAR2 results in high counting rates in the detectors that challenged the previously existing capture detection systems. For this reason, a Segmented Total Energy Detector (sTED) has been developed to overcome the limitations in the detector's response, by reducing the active volume per module and by using a photo-multiplier (PMT) optimized for high counting rates. This paper presents the main characteristics of the sTED, including energy and time resolution, response to gamma-rays, and provides as well details of the use of the Pulse Height Weighting Technique (PHWT) with this detector. The sTED has been validated to perform neutron-capture cross-section measurements in EAR2 in the neutron energy range from thermal up to at least 400 keV. The detector has already been successfully used in several measurements at nTOF EAR2.
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Alekhin, S. et al, & Hernandez, P. (2016). A facility to search for hidden particles at the CERN SPS: the SHiP physics case. Rep. Prog. Phys., 79(12), 124201–137pp.
Abstract: This paper describes the physics case for a new fixed target facility at CERN SPS. The SHiP (search for hidden particles) experiment is intended to hunt for new physics in the largely unexplored domain of very weakly interacting particles with masses below the Fermi scale, inaccessible to the LHC experiments, and to study tau neutrino physics. The same proton beam setup can be used later to look for decays of tau-leptons with lepton flavour number non-conservation, tau -> 3 μand to search for weakly-interacting sub-GeV dark matter candidates. We discuss the evidence for physics beyond the standard model and describe interactions between new particles and four different portals-scalars, vectors, fermions or axion-like particles. We discuss motivations for different models, manifesting themselves via these interactions, and how they can be probed with the SHiP experiment and present several case studies. The prospects to search for relatively light SUSY and composite particles at SHiP are also discussed. We demonstrate that the SHiP experiment has a unique potential to discover new physics and can directly probe a number of solutions of beyond the standard model puzzles, such as neutrino masses, baryon asymmetry of the Universe, dark matter, and inflation.
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Alencar, G., Estrada, M., Muniz, C. R., & Olmo, G. J. (2023). Dymnikova GUP-corrected black holes. J. Cosmol. Astropart. Phys., 11(11), 100–23pp.
Abstract: We consider the impact of Generalized Uncertainty Principle (GUP) effects on the Dymnikova regular black hole. The minimum length scale introduced by the GUP modifies the energy density associated with the gravitational source, referred to as the Dymnikova vacuum, based on its analogy with the gravitational counterpart of the Schwinger effect. We present an approximated analytical solution (together with exact numerical results for comparison) that encompasses a wide range of black hole sizes, whose properties crucially depend on the ratio between the de Sitter core radius and the GUP scale. The emergence of a wormhole inside the de Sitter core in the innermost region of the object is one of the most relevant features of this family of solutions. Our findings demonstrate that these solutions remain singularity free, confirming the robustness of the Dymnikova regular black hole under GUP corrections. Regarding energy conditions, we find that the violation of the strong, weak, and null energy conditions which is characteristic of the pure Dymnikova case does not occur at Planckian scales in the GUP corrected solution. This contrast suggests a departure from conventional expectations and highlights the influence of quantum corrections and the GUP in modifying the energy conditions near the Planck scale.
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HAWC Collaboration(Alfaro, R. et al), & Salesa Greus, F. (2022). Gamma/hadron separation with the HAWC observatory. Nucl. Instrum. Methods Phys. Res. A, 1039, 166984–13pp.
Abstract: The High Altitude Water Cherenkov (HAWC) gamma-ray observatory observes atmospheric showers produced by incident gamma rays and cosmic rays with energy from 300 GeV to more than 100 TeV. A crucial phase in analyzing gamma-ray sources using ground-based gamma-ray detectors like HAWC is to identify the showers produced by gamma rays or hadrons. The HAWC observatory records roughly 25,000 events per second, with hadrons representing the vast majority (> 99.9%) of these events. The standard gamma/hadron separation technique in HAWC uses a simple rectangular cut involving only two parameters. This work describes the implementation of more sophisticated gamma/hadron separation techniques, via machine learning methods (boosted decision trees and neural networks), and summarizes the resulting improvements in gamma/hadron separation obtained in HAWC.
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