| |
Records |
Links |
|
Author |
AGATA Collaboration; Doncel, M.; Recchia, F.; Quintana, B.; Gadea, A.; Farnea, E. |
|
| |
Title |
Experimental test of the background rejection, through imaging capability, of a highly segmented AGATA germanium detector |
Type |
Journal Article |
| |
Year |
2010 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
|
| |
Volume |
622 |
Issue |
3 |
Pages |
614-618 |
|
| |
Keywords |
Gamma spectroscopy; Gamma tracking; Imaging; Position-sensitive germanium detectors |
|
| |
Abstract |
The development of highly segmented germanium detectors as well as the algorithms to identify the position of the interaction within the crystal opens the possibility to locate the gamma-ray source using Compton imaging algorithms. While the Compton-suppression shield, coupled to the germanium detector in conventional arrays, works also as an active filter against the gamma rays originated outside the target, the new generation of position sensitive gamma-ray detector arrays has to fully rely on tracking capabilities for this purpose. In specific experimental conditions, as the ones foreseen at radioactive beam facilities, the ability to discriminate background radiation improves the sensitivity of the gamma spectrometer. In this work we present the results of a measurement performed at the Laboratori Nazionali di Legnaro (LNL) aiming the evaluation of the AGATA detector capabilities to discriminate the origin of the gamma rays on an event-by-event basis. It will be shown that, exploiting the Compton scattering formula, it is possible to track back gamma rays coming from different positions, assigning them to specific emitting locations. These imaging capabilities are quantified for a single crystal AGATA detector. |
|
| |
Address  |
[Doncel, M.; Quintana, B.] Univ Salamanca, Lab Radiac Ionizantes, E-37008 Salamanca, Spain, Email: doncel@usal.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0168-9002 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
ISI:000282562700017 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
257 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
AGATA Collaboration; Doncel, M.; Quintana, B.; Gadea, A.; Recchia, F.; Farnea, E. |
|
| |
Title |
Background rejection capabilities of a Compton imaging telescope setup with a DSSD Ge planar detector and AGATA |
Type |
Journal Article |
| |
Year |
2011 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
|
| |
Volume |
648 |
Issue |
|
Pages |
S131-S134 |
|
| |
Keywords |
gamma-Spectroscopy; Gamma tracking; Imaging; Position-sensitive germanium detectors |
|
| |
Abstract |
In this work, we show the first Monte Carlo results about the performance of the Ge array which we propose for the DESPEC experiment at FAIR, when the background algorithm developed for AGATA is applied. The main objective of our study is to characterize the capabilities of the gamma-spectroscopy system, made up of AGATA detectors in a semi-spherical distribution covering a 1 pi solid angle and a set of planar Ge detectors in a daisy configuration, to discriminate between gamma sources placed at different locations. |
|
| |
Address |
[Doncel, M.; Quintana, B.] Univ Salamanca, Lab Radiac Ionizantes, E-37008 Salamanca, Spain, Email: doncel@usal.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0168-9002 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000305376900035 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
1071 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
AGATA Collaboration; Domingo-Pardo, C.; Bazzacco, D.; Doornenbal, P.; Farnea, E.; Gadea, A.; Gerl, J.; Wollersheim, H.J. |
|
| |
Title |
Conceptual design and performance study for the first implementation of AGATA at the in-flight RIB facility of GSI |
Type |
Journal Article |
| |
Year |
2012 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
|
| |
Volume |
694 |
Issue |
|
Pages |
297-312 |
|
| |
Keywords |
gamma-Ray spectroscopy; Tracking; Monte Carlo |
|
| |
Abstract |
The main objective of the Advanced GAmma Tracking Array (AGATA) is the investigation of the structure of exotic nuclei at the new generation of RIB facilities. As part of the preparatory phase for FAIR-NUSTAR, AGATA is going to be installed at the FRS fragmentation facility of the GSI centre for an experimental campaign to be performed in 2012 and 2013. Owing to its gamma-ray tracking capabilities and the envisaged enhancement in resolving power, a series of in-flight gamma-ray spectroscopy experiments are being planned. The present work describes the conceptual design of this first implementation of AGATA at GSI-FRS, and provides information about the expected performance figures. According to the characteristics of each particular experiment, it is foreseen that the target-array distance is adjusted in order to achieve the optimum compromise between detection efficiency and energy resolution, or to cover an specific angular range of the emitted electromagnetic radiation. Thus, a comprehensive Monte Carlo study of the detection sensitivity in terms of photopeak efficiency, resolution and peak-to-total ratio, as a function of the target-array distance is presented. Several configurations have been investigated, and MC-calculations indicate that a remarkable enhancement in resolving power can be achieved when double-cluster AGATA detectors are developed and implemented. Several experimental effects are also investigated. This concerns the impact of passive materials between the target and the array, the angular distribution of the detection efficiency and the influence of target thickness effects and transition lifetimes in the attainable detection sensitivity. A short overview on half-life measurements via lineshape effects utilizing AGATA is also presented. (C) 2012 Elsevier B.V. All rights reserved. |
|
| |
Address |
[Domingo-Pardo, C.; Gadea, A.] Univ Valencia, CSIC, IFIC, Valencia, Spain, Email: domingo@ific.uv.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0168-9002 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000311020500041 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
1240 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
|
| |
Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
| |
Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
|
| |
Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
|
| |
Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
|
| |
Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
|
| |
Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Mdpi |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:001269841000001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
6204 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
AGATA Collaboration (Crespi, F.C.L. et al); Gadea, A. |
|
| |
Title |
Response of AGATA segmented HPGe detectors to gamma rays up to 15.1 MeV |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
|
| |
Volume |
705 |
Issue |
|
Pages |
47-54 |
|
| |
Keywords |
AGATA; Gamma-ray spectroscopy; Gamma-ray tracking; HPGe detectors; Pulse-shape and gamma-ray tracking algorithms; Semiconductor detector performance and simulations |
|
| |
Abstract |
The response of AGATA segmented HPGe detectors to gamma rays in the energy range 2-15 MeV was measured. The 15.1 MeV gamma rays were produced using the reaction d(B-11,n gamma)C-12 at E-beam=19.1 MeV, while gamma rays between 2 and 9 MeV were produced using an Am-Be-Fe radioactive source. The energy resolution and linearity were studied and the energy-to-pulse-height conversion resulted to be linear within 0.05%.Experimental interaction multiplicity distributions are discussed and compared with the results of Geant4 simulations. It is shown that the application of gamma-ray tracking allows a suppression of background radiation caused by n-capture in Ge nuclei. Finally the Doppler correction for the 15.1 MeV gamma line, performed using the position information extracted with Pulse-shape analysis is discussed. |
|
| |
Address |
[Crespi, F. C. L.; Avigo, R.; Camera, F.; Bottoni, S.; Bracco, A.; Ceruti, S.; Giaz, A.; Leoni, S.; Nicolini, R.; Pellegri, L.; Riboldi, S.; Vandone, V.] Univ Milan, Dipartimento Fis, I-20133 Milan, Italy, Email: fabio.crespi@mi.infn.it |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0168-9002 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000314826000009 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
1329 |
|
| Permanent link to this record |
