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ATLAS Collaboration(Aad, G. et al), Alvarez Piqueras, D., Aparisi Pozo, J. A., Bailey, A. J., Barranco Navarro, L., Cabrera Urban, S., et al. (2019). Resolution of the ATLAS muon spectrometer monitored drift tubes in LHC Run 2. J. Instrum., 14, P09011–35pp.
Abstract: The momentum measurement capability of the ATLAS muon spectrometer relies fundamentally on the intrinsic single-hit spatial resolution of the monitored drift tube precision tracking chambers. Optimal resolution is achieved with a dedicated calibration program that addresses the specific operating conditions of the 354 000 high-pressure drift tubes in the spectrometer. The calibrations consist of a set of timing offsets and drift time to drift distance transfer relations, and result in chamber resolution functions. This paper describes novel algorithms to obtain precision calibrations from data collected by ATLAS in LHC Run 2 and from a gas monitoring chamber, deployed in a dedicated gas facility. The algorithm output consists of a pair of correction constants per chamber which are applied to baseline calibrations, and determined to be valid for the entire ATLAS Run 2. The final single-hit spatial resolution, averaged over 1172 monitored drift tube chambers, is 81.7 +/- 2.2 μm.
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ATLAS Collaboration(Aad, G. et al), Alvarez Piqueras, D., Aparisi Pozo, J. A., Bailey, A. J., Cabrera Urban, S., Castillo, F. L., et al. (2019). Electron and photon performance measurements with the ATLAS detector using the 2015-2017 LHC proton-proton collision data. J. Instrum., 14, P12006–69pp.
Abstract: This paper describes the reconstruction of electrons and photons with the ATLAS detector, employed for measurements and searches exploiting the complete LHC Run 2 dataset. An improved energy clustering algorithm is introduced, and its implications for the measurement and identification of prompt electrons and photons are discussed in detail. Corrections and calibrations that affect performance, including energy calibration, identification and isolation efficiencies, and the measurement of the charge of reconstructed electron candidates are determined using up to 81 fb(-1) of proton-proton collision data collected at root s = 13 TeV between 2015 and 2017.
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Della Morte, M., Dooling, S., Heitger, J., Hesse, D., & Simma, H. (2014). Matching of heavy-light flavour currents between HQET at order 1/m and QCD: I. Strategy and tree-level study. J. High Energy Phys., 05(5), 060–31pp.
Abstract: We present a strategy how to match the full set of components of the heavy-light axial and vector currents in Heavy Quark Effective Theory (HQET), up to and including 1/m (h) -corrections, to QCD. While the ultimate goal is to apply these matching conditions non-perturbatively, in this study we first have implemented them at tree-level, in order to find good choices of the matching observables with small contributions. They can later be employed in the non-perturbative matching procedure which is a crucial part of precision HQET computations of semileptonic decay form factors in lattice QCD.
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Di Bari, P., King, S. F., & Hossain Rahat, M. (2024). Gravitational waves from phase transitions and cosmic strings in neutrino mass models with multiple majorons. J. High Energy Phys., 05(5), 068–31pp.
Abstract: We explore the origin of Majorana masses within the majoron model and how this can lead to the generation of a distinguishable primordial stochastic background of gravitational waves. We first show how in the simplest majoron model only a contribution from cosmic string can be within the reach of planned experiments. We then consider extensions containing multiple complex scalars, demonstrating how in this case a spectrum comprising contributions from both a strong first order phase transition and cosmic strings can naturally emerge. We show that the interplay between multiple scalar fields can amplify the phase transition signal, potentially leading to double peaks over the wideband sloped spectrum from cosmic strings. We also underscore the possibility of observing such a gravitational wave background to provide insights into the reheating temperature of the universe. We conclude highlighting how the model can be naturally combined with scenarios addressing the origin of matter of the universe, where baryogenesis occurs via leptogenesis and a right-handed neutrino plays the role of dark matter.
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Di Bari, P., Ludl, P. O., & Palomares-Ruiz, S. (2016). Unifying leptogenesis, dark matter and high-energy neutrinos with right-handed neutrino mixing via Higgs portal. J. Cosmol. Astropart. Phys., 11(11), 044–41pp.
Abstract: We revisit a model in which neutrino masses and mixing are described by a two right-handed (RH) neutrino seesaw scenario, implying a strictly hierarchical light neutrino spectrum. A third decoupled RH neutrino, N-DM with mass M-DM, plays the role of cold dark matter (DM) and is produced by the mixing with a source RH neutrino, Ns with mass M-S, induced by Higgs portal interactions. The same interactions are also responsible for N-DM decays. We discuss in detail the constraints coming from DM abundance and stability conditions showing that in the hierarchical case, for M-DM >> M-S, there is an allowed window on M-DM values necessarily implying a contribution, from DM decays, to the high-energy neutrino flux recently detected by IceCube. We also show how the model can explain the matter-antimatter asymmetry of the Universe via leptogenesis in the quasi-degenerate limit. In this case, the DM mass should be within the range 300 GeV less than or similar to M-S < M-DM < 10PeV. We discuss the specific properties of this high-energy neutrino flux and show the predicted event spectrum for two exemplary cases. Although DM decays, with a relatively hard spectrum, cannot account for all the IceCube high-energy data, we illustrate how this extra source of high-energy neutrinos could reasonably explain some potential features in the observed spectrum. In this way, this represents a unified scenario for leptogenesis and DM that could be tested during the next years with more high-energy neutrino events.
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Di Gregorio, E., Staelens, M., Hosseinkhah, N., Karimpoor, M., Liburd, J., Lim, L., et al. (2024). Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases. Nanomaterials, 14(13), 1093–21pp.
Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.
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Di Mauro, M., Donato, F., Fornengo, N., Lineros, R. A., & Vittino, A. (2014). Interpretation of AMS-02 electrons and positrons data. J. Cosmol. Astropart. Phys., 04(4), 006–33pp.
Abstract: We perform a combined analysis of the recent AMS-02 data on electrons, positrons, electrons plus positrons and positron fraction, in a self-consistent framework where we realize a theoretical modeling of all the astrophysical components that can contribute to the observed fluxes in the whole energy range. The primary electron contribution is modeled through the sum of an average flux from distant sources and the fluxes from the local supernova remnants in the Green catalog. The secondary electron and positron fluxes originate from interactions on the interstellar medium of primary cosmic rays, for which we derive a novel determination by using AMS-02 proton and helium data. Primary positrons and electrons from pulsar wind nebulae in the ATNF catalog are included and studied in terms of their most significant (while loosely known) properties and under different assumptions (average contribution from the whole catalog, single dominant pulsar, a few dominant pulsars). We obtain a remarkable agreement between our various modeling and the AMS-02 data for all types of analysis, demonstrating that the whole AMS-02 leptonic data admit a self-consistent interpretation in terms of astrophysical contributions.
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Di Valentino, E., Melchiorri, A., & Mena, O. (2013). Dark radiation sterile neutrino candidates after Planck data. J. Cosmol. Astropart. Phys., 11(11), 018–13pp.
Abstract: Recent Cosmic Microwave Background (CMB) results from the Planck satellite, combined with previous CMB data and Hubble constant measurements from the Hubble Space Telescope, provide a constraint on the effective number of relativistic degrees of freedom 3.62(-0.48)(+0.50) at 95% CL. New Planck data provide a unique opportunity to place limits on models containing relativistic species at the decoupling epoch. We present here the bounds on sterile neutrino models combining Planck data with galaxy clustering information. Assuming N-eff active plus sterile massive neutrino species, in the case of a Planck+WP+HighL+HST analysis we find m(nu,sterile)(eff) < 0.36 eV and 3.14 < N-eff < 4.15 at 95% CL, while using Planck+WP+HighL data in combination with the full shape of the galaxy power spectrum from the Baryon Oscillation Spectroscopic Survey BOSS Data Relase 9 measurements, we find that 3.30 < N-eff < 4.43 and m(nu,sterile)(eff) < 0.33 eV both at 95% CL with the three active neutrinos having the minimum mass allowed in the normal hierarchy scheme, i.e. Sigma m(nu) similar to 0.06 eV. These values compromise the viability of the (3 + 2) massive sterile neutrino models for the parameter region indicated by global fits of neutrino oscillation data. Within the (3 + 1) massive sterile neutrino scenario, we find m(nu,sterile)(eff) < 0.34 eV at 95% CL. While the existence of one extra sterile massive neutrino state is compatible with current oscillation data, the values for the sterile neutrino mass preferred by oscillation analyses are significantly higher than the current cosmological bound. We review as well the bounds on extended dark sectors with additional light species based on the latest Planck CMB observations.
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Diamanti, R., Ando, S., Gariazzo, S., Mena, O., & Weniger, C. (2017). Cold dark matter plus not-so-clumpy dark relics. J. Cosmol. Astropart. Phys., 06(6), 008–17pp.
Abstract: Various particle physics models suggest that, besides the (nearly) cold dark matter that accounts for current observations, additional but sub-dominant dark relics might exist. These could be warm, hot, or even contribute as dark radiation. We present here a comprehensive study of two-component dark matter scenarios, where the first component is assumed to be cold, and the second is a non-cold thermal relic. Considering the cases where the non-cold dark matter species could be either a fermion or a boson, we derive consistent upper limits on the non-cold dark relic energy density for a very large range of velocity dispersions, covering the entire range from dark radiation to cold dark matter. To this end, we employ the latest Planck Cosmic Microwave Background data, the recent BOSS DR11 and other Baryon Acoustic Oscillation measurements, and also constraints on the number of Milky Way satellites, the latter of which provides a measure of the suppression of the matter power spectrum at the smallest scales due to the free-streaming of the non-cold dark matter component. We present the results on the fraction f(ncdm) of non-cold dark matter with respect to the total dark matter for different ranges of the non-cold dark matter masses. We find that the 2 sigma limits for non-cold dark matter particles with masses in the range 1-10 keV are f(ncdm) <= 0.29 (0.23) for fermions (bosons), and for masses in the 10-100 keV range they are f(ncdm) <= 0.43 (0.45), respectively.
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Diamanti, R., Lopez-Honorez, L., Mena, O., Palomares-Ruiz, S., & Vincent, A. C. (2014). Constraining dark matter late-time energy injection: decays and p-wave annihilations. J. Cosmol. Astropart. Phys., 02(2), 017–24pp.
Abstract: We use the latest cosmic microwave background (CMB) observations to provide updated constraints on the dark matter lifetime as well as on p-wave suppressed annihilation cross sections in the 1 MeV to 1 TeV mass range. In contrast to scenarios with an s-wave dominated annihilation cross section, which mainly affect the CMB close to the last scattering surface, signatures associated with these scenarios essentially appear at low redshifts (z less than or similar to 50) when structure began to form, and thus manifest at lower multipoles in the CMB power spectrum. We use data from Planck, WMAP9, SPT and ACT, as well as Lyman-alpha measurements of the matter temperature at z similar to 4 to set a 95% confidence level lower bound on the dark matter lifetime of similar to 4 x 10(25) s for m(chi) = 100 MeV. This bound becomes lower by an order of magnitude at m(chi) = 1 TeV due to inefficient energy deposition into the inter-galactic medium. We also show that structure formation can enhance the effect of p-wave suppressed annihilation cross sections by many orders of magnitude with respect to the background cosmological rate, although even with this enhancement, CMB constraints are not yet strong enough to reach the thermal relic value of the cross section.
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