Perez-Calatayud, J., Ballester, F., Tedgren, C., DeWerd, L. A., Papagiannis, P., Rivard, M. J., et al. (2022). GEC-ESTRO ACROP recommendations on calibration and traceability of HE HDR-PDR photon-emitting brachytherapy sources at the hospital level. Radiother. Oncol., 176, 108–117.
Abstract: The vast majority of radiotherapy departments in Europe using brachytherapy (BT) perform temporary implants of high-or pulsed-dose rate (HDR-PDR) sources with photon energies higher than 50 keV. Such techniques are successfully applied to diverse pathologies and clinical scenarios. These recommen-dations are the result of Working Package 21 (WP-21) initiated within the BRAchytherapy PHYsics Quality Assurance System (BRAPHYQS) GEC-ESTRO working group with a focus on HDR-PDR source cal-ibration. They provide guidance on the calibration of such sources, including practical aspects and issues not specifically accounted for in well-accepted societal recommendations, complementing the BRAPHYQS WP-18 Report dedicated to low energy BT photon emitting sources (seeds). The aim of this report is to provide a European-wide standard in HDR-PDR BT source calibration at the hospital level to maintain high quality patient treatments.
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Fileviez Perez, P., & Murgui, C. (2019). Gamma lines from the hidden sector. Phys. Rev. D, 100(12), 123007–11pp.
Abstract: We discuss the visibility of gamma lines from dark matter annihilation. We point out a class of theories for dark matter which predict the existence of gamma lines with striking features. In these theories, the final state radiation processes are highly suppressed and one could distinguish easily the gamma lines from the continuum spectrum. We discuss the main experimental bounds and show that one could test the predictions for gamma lines in the near future in the context of simple gauge theories for dark matter.
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Fileviez Perez, P., Murgui, C., & Plascencia, A. D. (2019). Neutrino-dark matter connections in gauge theories. Phys. Rev. D, 100(3), 035041–14pp.
Abstract: We discuss the connection between the origin of neutrino masses and the properties of dark matter candidates in the context of gauge extensions of the Standard Model. We investigate minimal gauge theories for neutrino masses where the neutrinos arc predicted to be Dirac or Majorana fermions. We find that the upper bound on the effective number of relativistic species provides a strong constraint in the scenarios with Dirac neutrinos. In the context of theories where the lepton number is a local gauge symmetry spontaneously broken at the low scale, the existence of dark matter is predicted from the condition of anomaly cancellation. Applying the cosmological bound on the dark matter relic density, we find an upper bound on the symmetry breaking scale in the multi-TeV region. These results imply that we could test simple gauge theories for neutrino masses at current or future experiments.
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Fileviez Perez, P., Murgui, C., & Plascencia, A. D. (2019). The QCD axion and unification. J. High Energy Phys., 11(11), 093–21pp.
Abstract: The QCD axion is one of the most appealing candidates for the dark matter in the Universe. In this article, we discuss the possibility to predict the axion mass in the context of a simple renormalizable grand unified theory where the Peccei-Quinn scale is determined by the unification scale. In this framework, the axion mass is predicted to be in the range ma, <^> (3-13) x 10-9 eV. We study the axion phenomenology and find that the ABRACADABRA and CASPEr-Electric experiments will be able to fully probe this mass window.
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Fileviez Perez, P., Golias, E., Murgui, C., & Plascencia, A. D. (2020). The Higgs and leptophobic force at the LHC. J. High Energy Phys., 07(7), 087–19pp.
Abstract: The Higgs boson could provide the key to discover new physics at the Large Hadron Collider. We investigate novel decays of the Standard Model (SM) Higgs boson into leptophobic gauge bosons which can be light in agreement with all experimental constraints. We study the associated production of the SM Higgs and the leptophobic gauge boson that could be crucial to test the existence of a leptophobic force. Our results demonstrate that it is possible to have a simple gauge extension of the SM at the low scale, without assuming very small couplings and in agreement with all the experimental bounds that can be probed at the LHC.
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Fileviez Perez, P., Golias, E., Li, R. H., & Murgui, C. (2019). Leptophobic dark matter and the baryon number violation scale. Phys. Rev. D, 99(3), 035009–16pp.
Abstract: We discuss the possible connection between the scale for baryon number violation and the cosmological bound on the dark matter relic density. A simple gauge theory for baryon number which predicts the existence of a leptophobic cold dark matter particle candidate is investigated. In this context, the dark matter candidate is a Dirac fermion with mass defined by the new symmetry breaking scale. Using the cosmological bounds on the dark matter relic density we find the upper bound on the symmetry breaking scale around 200 TeV. The properties of the leptophobic dark matter candidate are investigated in great detail and we show the prospects to test this theory at current and future experiments. We discuss the main implications for the mechanisms to explain the matter and antimatter asymmetry in the Universe.
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Peppa, V., Thomson, R. M., Enger, S. A., Fonseca, G. P., Lee, C. N., Lucero, J. N. E., et al. (2023). A MC-based anthropomorphic test case for commissioning model-based dose calculation in interstitial breast 192-Ir HDR brachytherapy. Med. Phys., 50(7), 4675–4687.
Abstract: PurposeTo provide the first clinical test case for commissioning of Ir-192 brachytherapy model-based dose calculation algorithms (MBDCAs) according to the AAPM TG-186 report workflow. Acquisition and Validation MethodsA computational patient phantom model was generated from a clinical multi-catheter Ir-192 HDR breast brachytherapy case. Regions of interest (ROIs) were contoured and digitized on the patient CT images and the model was written to a series of DICOM CT images using MATLAB. The model was imported into two commercial treatment planning systems (TPSs) currently incorporating an MBDCA. Identical treatment plans were prepared using a generic Ir-192 HDR source and the TG-43-based algorithm of each TPS. This was followed by dose to medium in medium calculations using the MBDCA option of each TPS. Monte Carlo (MC) simulation was performed in the model using three different codes and information parsed from the treatment plan exported in DICOM radiation therapy (RT) format. Results were found to agree within statistical uncertainty and the dataset with the lowest uncertainty was assigned as the reference MC dose distribution. Data Format and Usage NotesThe dataset is available online at ,. Files include the treatment plan for each TPS in DICOM RT format, reference MC dose data in RT Dose format, as well as a guide for database users and all files necessary to repeat the MC simulations. Potential ApplicationsThe dataset facilitates the commissioning of brachytherapy MBDCAs using TPS embedded tools and establishes a methodology for the development of future clinical test cases. It is also useful to non-MBDCA adopters for intercomparing MBDCAs and exploring their benefits and limitations, as well as to brachytherapy researchers in need of a dosimetric and/or a DICOM RT information parsing benchmark. Limitations include specificity in terms of radionuclide, source model, clinical scenario, and MBDCA version used for its preparation.
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Penas, J., Alejo, A., Bembibre, A., Apiñaniz, J. I., Garcia-Garcia, E., Guerrero, C., et al. (2024). Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source. Sci Rep, 14(1), 11448–12pp.
Abstract: Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range.
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Penalva, N., Hernandez, E., & Nieves, J. (2022). Visible energy and angular distributions of the charged particle from the tau-decay in b -> C tau (mu(nu)over-bar(mu)nu(tau), pi nu(tau), rho nu(tau))(nu)over-bar(tau) reactions. J. High Energy Phys., 04(4), 026–25pp.
Abstract: We study the d(2)Gamma(d)/(d omega d cos theta(d) ), d Gamma(d)/d cos theta(d) and d Gamma(d)/dE(d) distributions, which are defined in terms of the visible energy and polar angle of the charged particle from the tau-decay in b -> C tau (mu(nu) over bar (mu)nu(tau), pi nu(tau), rho nu(tau))(nu) over bar (tau), reactions. These differential decay widths could be measured in the near future with certain precision. The first two contain information on the transverse tau-spin, tau-angular and tau-angular-spin asymmetries of the H-b -> H-c tau(nu) over bar (tau) parent decay and, from a dynamical point of view, they are richer than the commonly used one, d(2)Gamma(d)/(d omega dE(d)), since the latter only depends on the tau longitudinal polarization. We pay attention to the deviations with respect to the predictions of the standard model (SM) for these new observables, considering new physics (NP) operators constructed using both right- and left-handed neutrino fields, within an effective field-theory approach. We present results for Lambda(b) -> Lambda(c)tau (mu(nu) over bar (mu)nu(tau), pi nu(tau), rho nu(tau))(nu) over bar (tau) and (B) over bar -> D-(*()) tau (mu(nu) over bar (mu)nu(tau), pi nu(tau), rho nu(tau))(nu) over bar (tau) sequential decays and discuss their use to disentangle between different NP models. In this respect, we show that d Gamma(d)/d cos theta(d) , which should be measured with sufficiently good statistics, becomes quite useful, especially in the tau -> pi nu(tau) mode. The study carried out in this work could be of special relevance due to the recent LHCb measurement of the lepton flavor universality ratio R Lambda(c) in agreement with the SM. The experiment identified the tau using its hadron decay into pi(-)pi(+)pi(-)nu(tau), and this result for R Lambda(c )which is in conflict with the phenomenology from the b-meson sector, needs confirmation from other tau reconstruction channels.
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Penalva, N., Hernandez, E., & Nieves, J. (2021). New physics and the tau polarization vector in b -> c tau barnutau decays. J. High Energy Phys., 06(6), 118–37pp.
Abstract: For a general H-b -> Hc tau nu <overbar></mml:mover>tau decay we analyze the role of the tau polarization vector P μin the context of lepton flavor universality violation studies. We use a general phenomenological approach that includes, in addition to the Standard Model (SM) contribution, vector, axial, scalar, pseudoscalar and tensor new physics (NP) terms which strength is governed by, complex in general, Wilson coefficients. We show that both in the laboratory frame, where the initial hadron is at rest, and in the center of mass of the two final leptons, a P -></mml:mover> component perpendicular to the plane defined by the three-momenta of the final hadron and the tau lepton is only possible for complex Wilson coefficients, being a clear signal for physics beyond the SM as well as time reversal (or CP-symmetry) violation. We make specific evaluations of the different polarization vector components for the Lambda (b) -> Lambda (c), <mml:mover accent=“true”>B<mml:mo stretchy=“true”><overbar></mml:mover>c -> eta (c), J/psi and <mml:mover accent=“true”>B<mml:mo stretchy=“true”><overbar></mml:mover> -> D-(*) semileptonic decays, and describe NP effects in the complete two-dimensional space associated with the independent kinematic variables on which the polarization vector depends. We find that the detailed study of P μhas great potential to discriminate between different NP scenarios for 0(-) -> 0(-) decays, but also for Lambda (b) -> Lambda (c) transitions. For this latter reaction, we pay special attention to corrections to the SM predictions derived from complex Wilson coefficients contributions.
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