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Author |
Koolen, B.B.; Vidal-Sicart, S.; Benlloch, J.M.; Olmos, R.A.V. |
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Title |
Evaluating heterogeneity of primary tumor 18 F-FDG uptake in breast cancer with a dedicated breast PET ( MAMMI): a feasibility study based on correlation with PET/CT |
Type |
Journal Article |
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Year |
2014 |
Publication |
Nuclear Medicine Communications |
Abbreviated Journal |
Nucl. Med. Commun. |
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Volume |
35 |
Issue |
5 |
Pages |
446-452 |
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Keywords |
breast cancer; F-18-FDG; heterogeneity; MAMMI; PET |
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Abstract |
PurposeThe aim of the study was to evaluate the heterogeneity of primary tumor F-18-fluorodeoxyglucose (F-18-FDG) uptake in breast cancer patients using a dedicated breast PET.Patients and methodsA positron emission tomography/computed tomography (PET/CT) of the thorax was performed 60 min after administration of 180-240 MBq of F-18-FDG in patients with breast cancer. Subsequently, 110 min after injection, a scan was taken with a dedicated high-resolution breast PET [MAMmography with Molecular Imaging (MAMMI)]. Both procedures were performed with the patients in the prone position. Four-point scores were used to compare the intensity (0: none; 1: mild; 2: moderate; 3: high) and heterogeneity (0: none; 1: mild; 2: moderate; 3: high) of F-18-FDG uptake between PET/CT and MAMMI images.ResultsThirty-five patients in whom the primary tumor was visualized on both scans were included in this analysis. The mean primary tumor size was 35.1 mm (range 10-108 mm). The mean intensity score was similar on both devices (2.4 for PET/CT and 2.3 for MAMMI; P=0.439), but the mean heterogeneity score on MAMMI images was significantly higher (PET/CT 1.9 vs. MAMMI 2.3; P=0.005). MAMMI showed a higher heterogeneity score in 11 (31%) of 35 patients, especially in tumors with moderate or high intensity. Significantly higher heterogeneity scores on both PET/CT and MAMMI were seen in large tumors (P=0.005 and 0.014, respectively) and in tumors with high intensity scores (P=0.012 and P<0.001, respectively).ConclusionHeterogeneous tumor F-18-FDG uptake in breast cancer is frequently observed, particularly in large tumors with intense F-18-FDG uptake. It is more often seen on MAMMI PET than on conventional PET/CT. Although the observed heterogeneity should be proven histopathologically, this finding offers a rationale for F-18-FDG-guided biopsies. |
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Address  |
[Koolen, Bas B.; Vidal-Sicart, Sergi; Olmos, Renato A. Valdes] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Nucl Med, NL-1066 CX Amsterdam, Netherlands, Email: b.koolen@nki.nl |
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Lippincott Williams & Wilkins |
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English |
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ISSN |
0143-3636 |
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Notes |
WOS:000334103800002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1763 |
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Author |
T2K Collaboration (Abe, K. et al); Cervera-Villanueva, A.; Escudero, L.; Gomez-Cadenas, J.J.; Izmaylov, A.; Monfregola, L.; Sorel, M.; Stamoulis, P. |
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Title |
Observation of Electron Neutrino Appearance in a Muon Neutrino Beam |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
112 |
Issue |
6 |
Pages |
061802 - 8pp |
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Abstract |
The T2K experiment has observed electron neutrino appearance in a muon neutrino beam produced 295 km from the Super-Kamiokande detector with a peak energy of 0.6 GeV. A total of 28 electron neutrino events were detected with an energy distribution consistent with an appearance signal, corresponding to a significance of 7.3 sigma when compared to 4.92 +/- 0.55 expected background events. In the Pontecorvo-Maki-Nakagawa-Sakata mixing model, the electron neutrino appearance signal depends on several parameters including three mixing angles theta(12), theta(23), theta(13), a mass difference vertical bar Delta m(32)(2)vertical bar and a CP violating phase delta(CP). In this neutrino oscillation scenario, assuming vertical bar Delta m(32)(2)vertical bar = 2.4 x 10(-3) eV(2), sin theta(2)(23) = 0.5, and vertical bar Delta m(32)(2)vertical bar > 0 (vertical bar Delta m(32)(2)vertical bar < 0), a best- fit value of sin2 theta(2)(13) = 0.140(- 0.032)(+0.038) (0.170(-0.037)(+0.045)) is obtained at delta(CP) = 0. When combining the result with the current best knowledge of oscillation parameters including the world average value of theta(13) from reactor experiments, some values of delta(CP) are disfavored at the 90% C. L. |
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Address |
[Kitching, P.] Univ Alberta, Dept Phys, Ctr Particle Phys, Edmonton, AB, Canada |
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Amer Physical Soc |
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English |
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ISSN |
0031-9007 |
ISBN |
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Notes |
WOS:000331951000003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1701 |
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Author |
T2K Collaboration (Abe, K. et al); Cervera-Villanueva, A.; Escudero, L.; Gomez-Cadenas, J.J.; Izmaylov, A.; Monfregola, L.; Sorel, M.; Stamoulis, P. |
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Title |
Measurement of the intrinsic electron neutrino component in the T2K neutrino beam with the ND280 detector |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
89 |
Issue |
9 |
Pages |
092003 - 18pp |
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Keywords |
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Abstract |
The T2K experiment has reported the first observation of the appearance of electron neutrinos in a muon neutrino beam. The main and irreducible background to the appearance signal comes from the presence in the neutrino beam of a small intrinsic component of electron neutrinos originating from muon and kaon decays. In T2K, this component is expected to represent 1.2% of the total neutrino flux. A measurement of this component using the near detector (ND280), located 280 m from the target, is presented. The charged current interactions of electron neutrinos are selected by combining the particle identification capabilities of both the time projection chambers and electromagnetic calorimeters of ND280. The measured ratio between the observed electron neutrino beam component and the prediction is 1.01 +/- 0.10 providing a direct confirmation of the neutrino fluxes and neutrino cross section modeling used for T2K neutrino oscillation analyses. Electron neutrinos coming from muons and kaons decay are also separately measured, resulting in a ratio with respect to the prediction of 0.68 +/- 0.30 and 1.10 +/- 0.14, respectively. |
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Address |
[Kitching, P.] Univ Alberta, Dept Phys, Ctr Particle Phys, Edmonton, AB, Canada |
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Publisher |
Amer Physical Soc |
Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1550-7998 |
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Notes |
WOS:000336102000002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1796 |
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Author |
T2K Collaboration (Abe, K. et al); Cervera-Villanueva, A.; Escudero, L.; Izmaylov, A.; Monfregola, L.; Sorel, M.; Stamoulis, P. |
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Title |
Precise Measurement of the Neutrino Mixing Parameter theta(23) from Muon Neutrino Disappearance in an Off-Axis Beam |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
112 |
Issue |
18 |
Pages |
181801 - 8pp |
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Keywords |
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Abstract |
New data from the T2K neutrino oscillation experiment produce the most precise measurement of the neutrino mixing parameter theta(23). Using an off-axis neutrino beam with a peak energy of 0.6 GeV and a data set corresponding to 6.57 x 10(20) protons on target, T2K has fit the energy-dependent nu(mu) oscillation probability to determine oscillation parameters. The 68% confidence limit on sin(2)(theta(23)) is 0.514(-0.056)(+0.055) (0.511 +/- 0.055), assuming normal (inverted) mass hierarchy. The best-fit mass-squared splitting for normal hierarchy is Delta m(32)(2) = (2.51 +/- 0.10) x 10(-3) eV(2)/c(4) (inverted hierarchy: Delta m(13)(2) = (2.48 +/- 0.10) x 10(-3) eV(2)/c(4)). Adding a model of multinucleon interactions that affect neutrino energy reconstruction is found to produce only small biases in neutrino oscillation parameter extraction at current levels of statistical uncertainty. |
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Address |
[Kitching, P.] Univ Alberta, Dept Phys, Ctr Particle Phys, Edmonton, AB, Canada |
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Corporate Author |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Volume |
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ISSN |
0031-9007 |
ISBN |
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Conference |
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Notes |
WOS:000339629400005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1877 |
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Author |
T2K Collaboration (Abe, K. et al); Cervera-Villanueva, A.; Escudero, L.; Gomez-Cadenas, J.J.; Izmaylov, A.; Monfregola, L.; Sorel, M.; Stamoulis, P. |
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Title |
Measurement of the neutrino-oxygen neutral-current interaction cross section by observing nuclear deexcitation gamma rays |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
90 |
Issue |
7 |
Pages |
072012 - 11pp |
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Keywords |
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Abstract |
We report the first measurement of the neutrino-oxygen neutral-current quasielastic (NCQE) cross section gamma It is obtained by observing nuclear deexcitation. rays which follow neutrino-oxygen interactions at the Super-Kamiokande water Cherenkov detector. We use T2K data corresponding to 3.01 x 10(20) protons on target. By selecting only events during the T2K beam window and with well-reconstructed vertices in the fiducial volume, the large background rate from natural radioactivity is dramatically reduced. We observe 43 events in the 4-30 MeV reconstructed energy window, compared with an expectation of 51.0, which includes an estimated 16.2 background events. The background is primarily nonquasielastic neutral-current interactions and has only 1.2 events from natural radioactivity. The flux-averaged NCQE cross section we measure is 1.55 x 10(-38) cm(2) with a 68% confidence interval of (1.22, 2.20) x 10(-38) cm(2) at a median neutrino energy of 630 MeV, compared with the theoretical prediction of 2.01 x 10(-38) cm(2). |
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Address |
[Kitching, P.] Univ Alberta, Dept Phys, Ctr Particle Phys, Edmonton, AB, Canada |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1550-7998 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000344033100001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1993 |
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