| Records |
| Author |
Sanjuan, R.; Nebot, M.; Chirico, N.; Mansky, L.M.; Belshaw, R. |
| Title |
Viral Mutation Rates |
Type |
Journal Article |
| Year |
2010 |
Publication |
Journal of Virology |
Abbreviated Journal |
J. Virol. |
| Volume |
84 |
Issue |
19 |
Pages |
9733-9748 |
| Keywords |
|
Abstract  |
Accurate estimates of virus mutation rates are important to understand the evolution of the viruses and to combat them. However, methods of estimation are varied and often complex. Here, we critically review over 40 original studies and establish criteria to facilitate comparative analyses. The mutation rates of 23 viruses are presented as substitutions per nucleotide per cell infection (s/n/c) and corrected for selection bias where necessary, using a new statistical method. The resulting rates range from 10(-8) to 10(-6) s/n/c for DNA viruses and from 10(-6) to 10(-4) s/n/c for RNA viruses. Similar to what has been shown previously for DNA viruses, there appears to be a negative correlation between mutation rate and genome size among RNA viruses, but this result requires further experimental testing. Contrary to some suggestions, the mutation rate of retroviruses is not lower than that of other RNA viruses. We also show that nucleotide substitutions are on average four times more common than insertions/deletions (indels). Finally, we provide estimates of the mutation rate per nucleotide per strand copying, which tends to be lower than that per cell infection because some viruses undergo several rounds of copying per cell, particularly double-stranded DNA viruses. A regularly updated virus mutation rate data set will be available at www.uv.es/rsanjuan/virmut. |
| Address |
[Sanjuan, Rafael] Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolutiva, Dept Genet, Valencia 46980, Spain, Email: rafael.sanjuan@uv.es |
| Corporate Author |
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Thesis |
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| Publisher |
Amer Soc Microbiology |
Place of Publication |
|
Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0022-538x |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
ISI:000282641800008 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ elepoucu @ |
Serial |
371 |
| Permanent link to this record |
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| |
| Author |
Bonilla, C.; Nebot, M.; Valle, J.W.F.; Srivastava, R. |
| Title |
Flavor physics scenario for the 750 GeV diphoton anomaly |
Type |
Journal Article |
| Year |
2016 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
| Volume |
93 |
Issue |
7 |
Pages |
073009 - 5pp |
| Keywords |
|
| Abstract |
A simple variant of a realistic flavor symmetry scheme for fermion masses and mixings provides a possible interpretation of the diphoton anomaly as an electroweak singlet “flavon.” The existence of TeV scale vectorlike T-quarks required to provide adequate values for Cabibbo-Kobayashi-Maskawa (CKM) parameters can also naturally account for the diphoton anomaly. Correlations between V-ub and V-cb with the vectorlike T-quark mass can be predicted. Should the diphoton anomaly survive in a future run, our proposed interpretation can also be tested in upcoming B and LHC studies. |
| Address |
[Bonilla, Cesar; Nebot, Miguel; Valle, Jose W. F.] Univ Valencia, CSIC, Inst Fis Corpuscular, Parc Cient Paterna C Catedrat Jose Beltran 2, E-46980 Paterna, Valencia, Spain, Email: cesar.bonilla@ific.uv.es; |
| Corporate Author |
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Thesis |
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| Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
2470-0010 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000374548300003 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
2669 |
| Permanent link to this record |
