|
|
Peris, J. B., Davis, P., Cuevas, J. M., Nebot, M., & Sanjuan, R. (2010). Distribution of Fitness Effects Caused by Single-Nucleotide Substitutions in Bacteriophage f1. Genetics, 185(2), 603–U308.
Abstract: Empirical knowledge of the fitness effects of mutations is important for understanding many evolutionary processes, yet this knowledge is often hampered by several sources of measurement error and bias. Most of these problems can be solved using site-directed mutagenesis to engineer single mutations, an approach particularly suited for viruses due to their small genomes. Here, we used this technique to measure the fitness effect of 100 single-nucleotide substitutions in the bacteriophage f1, a filamentous single-strand DNA virus. We found that approximately one-fifth of all mutations are lethal. Viable ones reduced fitness by 11% on average and were accurately described by a log-normal distribution. More than 90% of synonymous substitutions were selectively neutral, while those affecting intergenic regions reduced fitness by 14% on average. Mutations leading to amino acid substitutions had an overall mean deleterious effect of 37%, which increased to 45% for those changing the amino acid polarity. Interestingly, mutations affecting early steps of the infection cycle tended to be more deleterious than those affecting late steps. Finally, we observed at least two beneficial mutations. Our results confirm that high mutational sensitivity is a general property of viruses with small genomes, including RNA and single-strand DNA viruses infecting animals, plants, and bacteria.
|
|
|
|
Aguilar, A. C., & Papavassiliou, J. (2010). Gluon mass generation without seagull divergences. Phys. Rev. D, 81(3), 034003–19pp.
Abstract: Dynamical gluon mass generation has been traditionally plagued with seagull divergences, and all regularization procedures proposed over the years yield finite but scheme-dependent gluon masses. In this work we show how such divergences can be eliminated completely by virtue of a characteristic identity, valid in dimensional regularization. The ability to trigger the aforementioned identity hinges crucially on the particular Ansatz employed for the three-gluon vertex entering into the Schwinger-Dyson equation governing the gluon propagator. The use of the appropriate three-gluon vertex brings about an additional advantage: one obtains two separate (but coupled) integral equations, one for the effective charge and one for the gluon mass. This system of integral equations has a unique solution, which unambiguously determines these two quantities. Most notably, the effective charge freezes in the infrared, and the gluon mass displays power-law running in the ultraviolet, in agreement with earlier considerations.
|
|
|
|
TAPS Collaboration, Piasecki, K., Matulewicz, T., Yahlali, N., Delagrange, H., Diaz, J., et al. (2010). Emission patterns of neutral pions in 40A MeV Ta plus Au reactions. Phys. Rev. C, 81(5), 054912–7pp.
Abstract: Differential cross sections of neutral pions emitted in Ta-181+Au-197 collisions at a beam energy of 39.5A Me V have been measured with the two-arm photon spectrometer (TAPS). The kinetic energy and transverse momentum spectra of neutral pions cannot be properly described in the framework of the thermal model, nor when the reabsorption of pions is accounted for in a phenomenological model. However, high energy and high momentum tails of the pion spectra can be well fitted through thermal distributions with unexpectedly soft temperature parameters below 10 MeV.
|
|
|
|
Pandolfi, S., Giusarma, E., Kolb, E. W., Lattanzi, M., Melchiorri, A., Mena, O., et al. (2010). Impact of general reionization scenarios on extraction of inflationary parameters. Phys. Rev. D, 82(12), 123527–10pp.
Abstract: Determination of whether the Harrison-Zel'dovich spectrum for primordial scalar perturbations is consistent with observations is sensitive to assumptions about the reionization scenario. In light of this result, we revisit constraints on inflationary models using more general reionization scenarios. While the bounds on the tensor-to-scalar ratio are largely unmodified, when different reionization schemes are addressed, hybrid models are back into the inflationary game. In the general reionization picture, we reconstruct both the shape and amplitude of the inflaton potential. We discuss how relaxing the simple reionization restriction affects the reconstruction of the potential through the changes in the constraints on the spectral index, the tensor-to-scalar ratio and the running of the spectral index. We also find that the inclusion of other Cosmic Microwave Background data in addition to the Wilkinson Microwave Anisotropy probe data excludes the very flat potentials typical of models in which the inflationary evolution reaches a late-time attractor, as a consequence of the fact that the running of the spectral index is constrained to be different from zero at 99% confidence level.
|
|
|
|
Razzaque, S., Jean, P., & Mena, O. (2010). High energy neutrinos from novae in symbiotic binaries: The case of V407 Cygni. Phys. Rev. D, 82(12), 123012–5pp.
Abstract: Detection of high-energy (>= 100 MeV) gamma rays by the Fermi Large Area Telescope from a nova in the symbiotic binary system V407 Cygni has opened the possibility of high-energy neutrino detection from this type of source. A thermonuclear explosion on the white dwarf surface sets off a nova shell in motion that expands and slows down in a dense surrounding medium provided by the red giant companion. Particles are accelerated in the shocks of the shell and interact with the surrounding medium to produce observed gamma rays. We show that proton-proton interaction, which is most likely responsible for producing gamma rays via neutral pion decay, produces >= 0:1 GeV neutrinos that can be detected by the current and future experiments at >= 10 GeV.
|
|
