|
|
Ruhr, F. et al, Escobar, C., & Miñano, M. (2020). Testbeam studies of barrel and end-cap modules for the ATLAS ITk strip detector before and after irradiation. Nucl. Instrum. Methods Phys. Res. A, 979, 164430–6pp.
Abstract: In order to cope with the occupancy and radiation doses expected at the High-Luminosity LHC, the ATLAS experiment will replace its Inner Detector with an all-silicon Inner Tracker (ITk), consisting of pixel and strip subsystems. In the last two years, several prototype ITk strip modules have been tested using beams of high energy electrons produced at the DESY-II testbeam facility. Tracking was provided by EUDET telescopes. The modules tested are built from two sensor types: the rectangular ATLAS17LS, which will be used in the outer layers of the central barrel region of the detector, and the annular ATLAS12EC, which will be used in the innermost ring (R0) of the forward region. Additionally, a structure with two RO modules positioned back-to-back has been measured, demonstrating space point reconstruction using the stereo angle of the strips. Finally, one barrel and one RO module have been measured after irradiation to 40% beyond the expected end-of-lifetime fluence. The data obtained allow for thorough tests of the module performance, including charge collection, noise occupancy, detection efficiency, and tracking performance. The results give confidence that the ITk strip detector will meet the requirements of the ATLAS experiment.
|
|
|
|
Di Gregorio, E., Staelens, M., Hosseinkhah, N., Karimpoor, M., Liburd, J., Lim, L., et al. (2024). Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases. Nanomaterials, 14(13), 1093–21pp.
Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.
|
|
|
|
Boudet, S., Bombacigno, F., Moretti, F., & Olmo, G. J. (2023). Torsional birefringence in metric-affine Chern-Simons gravity: gravitational waves in late-time cosmology. J. Cosmol. Astropart. Phys., 01(1), 026–28pp.
Abstract: In the context of the metric-affine Chern-Simons gravity endowed with projective invariance, we derive analytical solutions for torsion and nonmetricity in the homogeneous and isotropic cosmological case, described by a flat Friedmann-Robertson-Walker metric. We discuss in some details the general properties of the cosmological solutions in the presence of a perfect fluid, such as the dynamical stability and the emergence of big bounce points, and we examine the structure of some specific solutions reproducing de Sitter and power law behaviours for the scale factor. Then, we focus on first-order perturbations in the de Sitter scenario, and we study the propagation of gravitational waves in the adiabatic limit, looking at tensor and scalar polarizations. In particular, we find that metric tensor modes couple to torsion tensor components, leading to the appearance, as in the metric version of Chern-Simons gravity, of birefringence, characterized by different dispersion relations for the left and right circularized polarization states. As a result, the purely tensor part of torsion propagates like a wave, while nonmetricity decouples and behaves like a harmonic oscillator. Finally, we discuss scalar modes, outlining as they decay exponentially in time and do not propagate.
|
|
|
|
KM3NeT Collaboration(Aitllo, S. et al), Alves Garre, S., Calvo, D., Carretero, V., Garcia Soto, A., Gozzini, S. R., et al. (2023). Probing invisible neutrino decay with KM3NeT/ORCA. J. High Energy Phys., 04(4), 090–30pp.
Abstract: In the era of precision measurements of the neutrino oscillation parameters, upcoming neutrino experiments will also be sensitive to physics beyond the Standard Model. KM3NeT/ORCA is a neutrino detector optimised for measuring atmospheric neutrinos from a few GeV to around 100 GeV. In this paper, the sensitivity of the KM3NeT/ORCA detector to neutrino decay has been explored. A three-flavour neutrino oscillation scenario, where the third neutrino mass state v3 decays into an invisible state, e.g. a sterile neutrino, is considered. We find that KM3NeT/ORCA would be sensitive to invisible neutrino decays with 1/alpha 3 = T3/m3 < 180 ps/eV at 90% confidence level, assuming true normal ordering. Finally, the impact of neutrino decay on the precision of KM3NeT/ORCA measurements for theta(23), Delta m(31)(2) and mass ordering have been studied. No significant effect of neutrino decay on the sensitivity to these measurements has been found.
|
|
|
|
Gariazzo, S., de Salas, P. F., & Pastor, S. (2019). Thermalisation of sterile neutrinos in the early universe in the 3+1 scheme with full mixing matrix. J. Cosmol. Astropart. Phys., 07(7), 014–30pp.
Abstract: In the framework of a 3+1 scheme with an additional inert state, we consider the thermalisation of sterile neutrinos in the early Universe taking into account the full 4 x 4 mixing matrix. The evolution of the neutrino energy distributions is found solving the momentum-dependent kinetic equations with full diagonal collision terms, as in previous analyses of flavour neutrino decoupling in the standard case. The degree of thermalisation of the sterile state is shown in terms of the effective number of neutrinos, N-eff, and its dependence on the three additional mixing angles (theta(14), theta(24), theta(34)) and on the squared mass difference Delta m(41)(2) is discussed. Our results are relevant for fixing the contribution of a fourth light neutrino species to the cosmological energy density, whose value is very well constrained by the final Planck analysis. For the preferred region of active-sterile mixing parameters from short-baseline neutrino experiments, we find that the fourth state is fully thermalised (N-eff similar or equal to 4).
|
|
|
|
Bouhova-Thacker, E., Kostyukhin, V., Koffas, T., Liebig, W., Limper, M., Piacquadio, G. N., et al. (2010). Expected Performance of Vertex Reconstruction in the ATLAS Experiment at the LHC. IEEE Trans. Nucl. Sci., 57(2), 760–767.
Abstract: In the harsh environment of the Large Hadron Collider at CERN (design luminosity of 10(34) cm(-2) s(-1)) efficient reconstruction of vertices is crucial for many physics analyses. Described in this paper is the expected performance of the vertex reconstruction used in the ATLAS experiment. The algorithms for the reconstruction of primary and secondary vertices as well as for finding photon conversions and vertex reconstruction in jets are described. The implementation of vertex algorithms which follows a very modular design based on object-oriented C++ is presented. A user-friendly concept allows event reconstruction and physics analyses to compare and optimize their choice among different vertex reconstruction strategies. The performance of implemented algorithms has been studied on a variety of Monte Carlo samples and results are presented.
|
|
|
|
Kuehn, S. et al, Bernabeu, J., Lacasta, C., Marco-Hernandez, R., Rodriguez Rodriguez, D., Santoyo, D., et al. (2018). Prototyping of petalets for the Phase-II upgrade of the silicon strip tracking detector of the ATLAS experiment. J. Instrum., 13, T03004–22pp.
Abstract: In the high luminosity era of the Large Hadron Collider, the instantaneous luminosity is expected to reach unprecedented values, resulting in about 200 proton-proton interactions in a typical bunch crossing. To cope with the resultant increase in occupancy, bandwidth and radiation damage, the ATLAS Inner Detector will be replaced by an all-silicon system, the Inner Tracker (ITk). The ITk consists of a silicon pixel and a strip detector and exploits the concept of modularity. Prototyping and testing of various strip detector components has been carried out. This paper presents the developments and results obtained with reduced-size structures equivalent to those foreseen to be used in the forward region of the silicon strip detector. Referred to as petalets, these structures are built around a composite sandwich with embedded cooling pipes and electrical tapes for routing the signals and power. Detector modules built using electronic flex boards and silicon strip sensors are glued on both the front and back side surfaces of the carbon structure. Details are given on the assembly, testing and evaluation of several petalets. Measurement results of both mechanical and electrical quantities are shown. Moreover, an outlook is given for improved prototyping plans for large structures.
|
|
|
|
n_TOF Collaboration(Bacak, M. et al), Domingo-Pardo, C., & Tain, J. L. (2020). A compact fission detector for fission-tagging neutron capture experiments with radioactive fissile isotopes. Nucl. Instrum. Methods Phys. Res. A, 969, 163981–10pp.
Abstract: In the measurement of neutron capture cross-sections of fissile isotopes, the fission channel is a source of background which can be removed efficiently using the so-called fission-tagging or fission-veto technique. For this purpose a new compact and fast fission chamber has been developed. The design criteria and technical description of the chamber are given within the context of a measurement of the U-233(n, gamma) cross-section at the nTOF facility at CERN, where it was coupled to the nTOF Total Absorption Calorimeter. For this measurement the fission detector was optimized for time resolution, minimization of material in the neutron beam and for alpha-fission discrimination. The performance of the fission chamber and its application as a fission tagging detector are discussed.
|
|
|
|
Aristizabal Sierra, D., Tortola, M., Valle, J. W. F., & Vicente, A. (2014). Leptogenesis with a dynamical seesaw scale. J. Cosmol. Astropart. Phys., 07(7), 052–20pp.
Abstract: In the simplest type-I seesaw leptogenesis scenario right-handed neutrino annihilation processes are absent. However, in the presence of new interactions these processes are possible and can affect the resulting B – L asymmetry in an important way. A prominent example is provided by models with spontaneous lepton number violation, where the existence of new dynamical degrees of freedom can play a crucial role. In this context, we provide a model-independent discussion of the effects of right-handed neutrino annihilations. We show that in the weak washout regime, as long as the scattering processes remain slow compared with the Hubble expansion rate throughout the relevant temperature range, the efficiency can be largely enhanced, reaching in some cases maximal values. Moreover, the B – L asymmetry yield turns out to be independent upon initial conditions, in contrast to the “standard” case. On the other hand, when the annihilation processes are fast, the right-handed neutrino distribution tends to a thermal one down to low temperatures, implying a drastic suppression of the efficiency which in some cases can render the B – L generation mechanism inoperative.
|
|
|
|
Azevedo, C. D. R., Baeza, A., Chauveau, E., Corbacho, J. A., Diaz, J., Domange, J., et al. (2023). Design, setup and routine operation of a water treatment system for the monitoring of low activities of tritium in water. Nucl. Eng. Technol., 55(7), 2349–2355.
Abstract: In the TRITIUM project, an on-site monitoring system is being developed to measure tritium (3H) levels in water near nuclear power plants. The quite low-energy betas emitted by 3H have a very short average path in water (5 mm as shown by simulations for 18 keV electrons). This path would be further reduced by impurities present in the water, resulting in a significant reduction of the detection efficiency. Therefore, one of the essential requirements of the project is the elimination of these impurities through a filtration process and the removal of salts in solution. This paper describes a water treatment system developed for the project that meets the following requirements: the water produced should be of nearpure water quality according to ISO 3696 grade 3 standard (conductivity < 10 mS/cm); the system should operate autonomously and be remotely monitored.
|
|
