Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.

Abstract: In this paper we discuss SU(5)3 with cyclic symmetry as a possible grand unified theory (GUT). The basic idea of such a tri-unification is that there is a separate SU(5) for each fermion family, with the light Higgs doublet(s) arising from the third family SU(5), providing a basis for charged fermion mass hierarchies. SU(5)3 tri-unification reconciles the idea of gauge non-universality with the idea of gauge coupling unification, opening the possibility to build consistent non-universal descriptions of Nature that are valid all the way up to the scale of grand unification. As a concrete example, we propose a grand unified embedding of the tri-hypercharge model \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\text{U}}{\left(1\right)}_{Y}<^>{3}$$\end{document} based on an SU(5)3 framework with cyclic symmetry. We discuss a minimal tri-hypercharge example which can account for all the quark and lepton (including neutrino) masses and mixing parameters. We show that it is possible to unify the many gauge couplings into a single gauge coupling associated with the cyclic SU(5)3 gauge group, by assuming minimal multiplet splitting, together with a set of relatively light colour octet scalars. We also study proton decay in this example, and present the predictions for the proton lifetime in the dominant e+pi 0 channel.

Abstract: In this work, by a novel approach to studying the scattering of a Schwarzschild black hole, the non-commutativity is introduced as perturbation. We begin by reformulating the Klein-Gordon equation for the scalar field in a new form that takes into account the deformed non-commutative spacetime. Using this formulation, an effective potential for the scattering process is derived. To calculate the quasinormal modes, we employ the WKB method and also utilize fitting techniques to investigate the impact of non-commutativity on the scalar quasinormal modes. We thoroughly analyze the results obtained from these different methods. Moreover, the greybody factor and absorption cross section are investigated. Additionally, we explore the behavior of null geodesics in the presence of non-commutativity. Specifically, we examine the photonic, and shadow radius as well as the light trajectories for different non-commutative parameters. Therefore, by addressing these various aspects, we aim to provide a comprehensive understanding of the influence of non-commutativity on the scattering of a Schwarzschild-like black hole and its implications for the behavior of scalar fields and light trajectories.

Abstract: Measurements of the suppression and correlations of dijets is performed using 3 μb(-1) of Xe+Xe data at root sNN = 5.44 TeV collected with the ATLAS detector at the CERN Large Hadron Collider. Dijets with jets reconstructed using the R = 0.4 anti-kt algorithm are measured differentially in jet p(T) over the range of 32 to 398 GeV and the centrality of the collisions. Significant dijet momentum imbalance is found in the most central Xe+Xe collisions, which decreases in more peripheral collisions. Results from the measurement of per-pair normalized and absolutely normalized dijet p(T) balance are compared with previous Pb+Pb measurements at root sNN = 5.02 TeV. The differences between the dijet suppression in Xe+Xe and Pb+Pb are further quantified by the ratio of pair nuclear-modification factors. The results are found to be consistent with those measured in Pb+Pb data when compared in classes of the same event activity and when taking into account the difference between the center-of-mass energies of the initial parton scattering process in Xe+Xe and Pb+Pb collisions. These results should provide input for a better understanding of the role of energy density, system size, path length, and fluctuations in the parton energy loss.

Abstract: One long-standing tension in the determination of neutrino parameters is the mismatched value of the solar mass square difference, Delta m(21)(2), measured by different experiments: the reactor antineutrino experiment KamLAND finds a best fit larger than the one obtained with solar neutrino data. Even if the current tension is mild (similar to 1.5 sigma.), it is timely to explore if independent measurements could help in either closing or reassessing this issue. In this regard, we explore how a future supernova burst in our galaxy could be used to determine Delta m(21)(2) at the future Hyper-Kamiokande detector, and how this could contribute to the current situation. We study Earth matter effects for different models of supernova neutrino spectra and supernova orientations. We find that, if supernova neutrino data prefers the KamLAND best fit for Delta m(21)(2), an uncertainty similar to the current KamLAND one could be achieved. On the contrary, if it prefers the solar neutrino data best fit, the current tension with KamLAND results could grow to a significance larger than 5 sigma. Furthermore, supernova neutrinos could significantly contribute to reducing the uncertainty on sin (2)theta(12).