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Sanjuan, R., Nebot, M., Peris, J. B., & Alcami, J. (2013). Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1. PLoS. Biol., 11(4), e1001523–10pp.
Abstract: The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive.
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Bernabeu, J., Botella, F. J., & Nebot, M. (2014). Novel T-Violation observable open to any pair of decay channels at meson factories. Phys. Lett. B, 728, 95–98.
Abstract: Quantum entanglement between the two neutral mesons produced in meson factories has allowed the first indisputable direct observation of Time Reversal Violation in the time evolution of the neutral meson between the two decays. The exceptional meson transitions are directly connected to semileptonic and CP eigenstate decay channels. The possibility of extending the observable asymmetries to more decay channels confronts the problem of the “orthogonality condition”, which can be stated with this tonguetwister: Given a decay channel f, which is the decay channel f' such that the meson state not decaying to f is orthogonal to the meson state not decaying to f? In this Letter we propose an alternative T-Violation asymmetry at meson factories which allows its opening to any pair of decay channels. Instead of searching which is the pair of decay channels associated to the T-reverse meson transition, we build an asymmetry which tags the initial states of both the Reference and the T-reverse meson transitions. This observable filters the appropriate final states by means of two measurable survival probabilities. We discuss the methodology to be followed in the analysis of the new observable and the results expected in specific examples.
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Nebot, M. (2020). Bounded masses in two Higgs doublets models, spontaneous CP violation and Z(2) symmetry. Phys. Rev. D, 102(11), 115002–16pp.
Abstract: In two Higgs doublet models (2HDMs) shaped by some unbroken symmetry, imposing perturbativity requirements on the quartic couplings can imply that the allowed masses of all the fundamental scalars are bounded from above. This important property is analyzed in detail for the only two realistic 2HDMs with an exact symmetry, the case with Z(2) symmetry and the case with CP symmetry. It is also noticeable that one exception arises in each case: when the vacuum is assumed to respect the imposed symmetry, a decoupling regime can nevertheless appear without violating perturbativity requirements. In both models with an exact symmetry and no decoupling regime, soft symmetry breaking terms can however lead to a decoupling regime: the possibility that this regime might be unnatural, since it requires some fine-tuning, is also analyzed.
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Bernabeu, J., Botella, F. J., Mavromatos, N. E., & Nebot, M. (2017). The signal of ill-defined CPT weakening entanglement in the B-d system. Eur. Phys. J. C, 77(12), 865–10pp.
Abstract: In the presence of quantum-gravity fluctuations (space-time foam), the CPT operator may be ill-defined. Its perturbative treatment leads to a modification of the Einstein-Podolsky- Rosen correlation of the neutral meson system by adding an entanglement-weakening term of the wrong exchange symmetry, the omega-effect. In the current paper we identify how to probe the complex omega in the entangled B-d system using the flavour (f)-CP(g) eigenstate decay channels: the connection between the intensities for the two timeordered decays (f, g) and (g, f) is lost. Appropriate observables are constructed allowing independent experimental determinations of Re(omega) and Im(omega), disentangled from CPT violation in the evolution Hamiltonian Re(theta) and Im(theta). 2 sigma tensions for both Re(theta) and Im(omega) are shown to be uncorrelated.
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Alves, J. M., Botella, F. J., Miro, C., & Nebot, M. (2023). Spontaneous CP violation and μ-τ symmetry intwo-Higgs-doublet models with flavour conservation. Eur. Phys. J. C, 83(10), 940–12pp.
Abstract: In multi-Higgs-doublet models, requiring simultaneously that (i) CP violation only arises spontaneously, (ii)tree level scalar flavour changing couplings are absent and (iii) the fermion mixing matrix is CP violating, can only be achieved in a very specific manner. A general approach with new clarifying insights on the question is presented. Considering the quark sector, that peculiar possibility is not viable on phenomenological grounds. We show that, considering the lepton sector, it is highly interesting and leads to viable models with mu-tau symmetric PMNS matrices. Phenomenological implications of the models, both for Dirac and Majorana (in a type I seesaw scenario) neutrinos, are analysed.
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