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Muñoz, E., Barrientos, L., Bernabeu, J., Borja-Lloret, M., Llosa, G., Ros, A., et al. (2020). A spectral reconstruction algorithm for two-plane Compton cameras. Phys. Med. Biol., 65(2), 025011–17pp.
Abstract: One factor limiting the current applicability extent of hadron therapy is the lack of a reliable method for real time treatment monitoring. The use of Compton imaging systems as monitors requires the correct reconstruction of the distribution of prompt gamma productions during patient irradiation. In order to extract the maximum information from all the measurable events, we implemented a spectral reconstruction method that assigns to all events a probability of being either partial or total energy depositions. The method, implemented in a list-mode maximum likelihood expectation maximization algorithm, generates a four dimensional image in the joint spatial-spectral domain, in which the voxels containing the emission positions and energies are obtained. The analytical model used for the system response function is also employed to derive an analytical expression for the sensitivity, which is calculated via Monte Carlo integration. The performance of the method is evaluated through reconstruction of various experimental and simulated sources with different spatial and energy distributions. The results show that the proposed method can recover the spectral and spatial information simultaneously, but only under the assumption of ideal measurements. The analysis of the Monte Carlo simulations has led to the identification of two important degradation sources: the mispositioning of the gamma interaction point and the missing energy recorded in the interaction. Both factors are related to the high energy transferred to the recoil electrons, which can travel far from the interaction point and even escape the detector. These effects prevent the direct application of the current method in more realistic scenarios. Nevertheless, experimental point-like sources have been accurately reconstructed and the spatial distributions and spectral emission of complex simulated phantoms can be identified.
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NEXT Collaboration(Renner, J. et al), Martinez-Lema, G., Alvarez, V., Benlloch-Rodriguez, J. M., Botas, A., Carcel, S., et al. (2018). Initial results on energy resolution of the NEXT-White detector. J. Instrum., 13, P10020–14pp.
Abstract: One of the major goals of the NEXT-White (NEW) detector is to demonstrate the energy resolution that an electroluminescent high pressure xenon TPC can achieve for high energy tracks. For this purpose, energy calibrations with Cs-137 and Th-232 sources have been carried out as a part of the long run taken with the detector during most of 2017. This paper describes the initial results obtained with those calibrations, showing excellent linearity and an energy resolution that extrapolates to approximately 1% FWHM at Q(beta beta).
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Giare, W., Renzi, F., Melchiorri, A., Mena, O., & Di Valentino, E. (2022). Cosmological forecasts on thermal axions, relic neutrinos, and light elements. Mon. Not. Roy. Astron. Soc., 511(1), 1373–1382.
Abstract: One of the targets of future cosmic microwave background (CMB) and baryon acoustic oscillation measurements is to improve the current accuracy in the neutrino sector and reach a much better sensitivity on extra dark radiation in the early Universe. In this paper, we study how these improvements can be translated into constraining power for well-motivated extensions of the standard model of elementary particles that involve axions thermalized before the quantum chromodynamics (QCD) phase transition by scatterings with gluons. Assuming a fiducial Lambda cold dark matter cosmological model, we simulate future data for Stage-IV CMB-like and Dark Energy Spectroscopic Instrument (DESI)-like surveys and analyse a mixed scenario of axion and neutrino hot dark matter. We further account also for the effects of these QCD axions on the light element abundances predicted by big bang nucleosynthesis. The most constraining forecasted limits on the hot relic masses are m(a) less than or similar to 0.92 eV and n-ary sumation m(nu) less than or similar to 0.12 eV at 95 per cent Confidence Level, showing that future cosmic observations can substantially improve the current bounds, supporting multimessenger analyses of axion, neutrino, and primordial light element properties.
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Torres-Espallardo, I., Diblen, F., Rohling, H., Solevi, P., Gillam, J., Watts, D., et al. (2015). Evaluation of resistive-plate-chamber-based TOF-PET applied to in-beam particle therapy monitoring. Phys. Med. Biol., 60(9), N187–N208.
Abstract: Particle therapy is a highly conformal radiotherapy technique which reduces the dose deposited to the surrounding normal tissues. In order to fully exploit its advantages, treatment monitoring is necessary to minimize uncertainties related to the dose delivery. Up to now, the only clinically feasible technique for the monitoring of therapeutic irradiation with particle beams is Positron Emission Tomography (PET). In this work we have compared a Resistive Plate Chamber (RPC)-based PET scanner with a scintillation-crystal-based PET scanner for this application. In general, the main advantages of the RPC-PET system are its excellent timing resolution, low cost, and the possibility of building large area systems. We simulated a partial-ring scannerbeam monitoring, which has an intrinsically low positron yield compared to diagnostic PET. In addition, for in-beam PET there is a further data loss due to the partial ring configuration. In order to improve the performance of the RPC-based scanner, an improved version of the RPC detector (modifying the thickness of the gas and glass layers), providing a larger sensitivity, has been simulated and compared with an axially extended version of the crystal-based device. The improved version of the RPC shows better performance than the prototype, but the extended version of the crystal-based PET outperforms all other options. based on an RPC prototype under construction within the Fondazione per Adroterapia Oncologica (TERA). For comparison with the crystal-based PET scanner we have chosen the geometry of a commercially available PET scanner, the Philips Gemini TF. The coincidence time resolution used in the simulations takes into account the current achievable values as well as expected improvements of both technologies. Several scenarios (including patient data) have been simulated to evaluate the performance of different scanners. Initial results have shown that the low sensitivity of the RPC hampers its application to hadron
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de Souza, P. M., Muller, A., Beniaich, A., Mayer-Miebach, E., Oehlke, K., Stahl, M., et al. (2015). Functional properties and nutritional composition of liquid egg products treated in a coiled tube UV-C reactor. Innov. Food Sci. Emerg. Technol., 32, 156–164.
Abstract: Pasteurization of eggs has adverse effects on nutrient composition and functionality of egg proteins. UV processing is an alternative technology with potentially fewer adverse effects as it is less intrusive. Egg white, whole egg and egg yolk vitamins (A, B-2, B-5, C and E), minerals (P, Cl, K, Na, Ca, Mg, Fe and Zn) and main secondary metabolites (lutein and zeaxanthin) were examined after exposure to UV in a coiled tube UV-C reactor at doses known to achieve microbiologically stable egg fractions. The studied nutrients were fairly stable to a treatment with UVC light with the exception of retinal, vitamin C and carotenoids, which showed loses up to 80%, 66% and 61%, respectively. Moreover, the functional properties of ultraviolet-treated eggs were investigated. Results showed a positive impact on the foam ability and foam stability, and an increase on the emulsifying activity index above 20% versus pasteurized samples. Processing with UV can maintain most of the egg nutritive properties, and retain or even improve the technological properties of foaming and emulsification in eggs. Industrial relevance:: This novel UV-C system can be applied successfully to the Food Industry. UV-C does not impair nutritional damage to egg-treated products, and even improve egg functional properties.
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