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Garonna, A., Amaldi, U., Bonomi, R., Campo, D., Degiovanni, A., Garlasche, M., et al. (2010). Cyclinac medical accelerators using pulsed C6+/H-2(+) ion sources. J. Instrum., 5, C09004–19pp.
Abstract: Charged particle therapy, or so-called hadrontherapy, is developing very rapidly. There is large pressure on the scientific community to deliver dedicated accelerators, providing the best possible treatment modalities at the lowest cost. In this context, the Italian research Foundation TERA is developing fast-cycling accelerators, dubbed 'cyclinacs'. These are a combination of a cyclotron (accelerating ions to a fixed initial energy) followed by a high gradient linac boosting the ions energy up to the maximum needed for medical therapy. The linac is powered by many independently controlled klystrons to vary the beam energy from one pulse to the next. This accelerator is best suited to treat moving organs with a 4D multipainting spot scanning technique. A dual proton/carbon ion cyclinac is here presented. It consists of an Electron Beam Ion Source, a superconducting isochronous cyclotron and a high-gradient linac. All these machines are pulsed at high repetition rate (100-400 Hz). The source should deliver both C6+ and H-2(+) ions in short pulses (1.5 μs flat-top) and with sufficient intensity (at least 10(8) fully stripped carbon ions per pulse at 300 Hz). The cyclotron accelerates the ions to 120 MeV/u. It features a compact design (with superconducting coils) and a low power consumption. The linac has a novel C-band high-gradient structure and accelerates the ions to variable energies up to 400 MeV/u. High RF frequencies lead to power consumptions which are much lower than the ones of synchrotrons for the same ion extraction energy. This work is part of a collaboration with the CLIC group, which is working at CERN on high-gradient electron-positron colliders.
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Llosa, G., Barrio, J., Lacasta, C., Callier, S., Raux, L., & de La Taille, C. (2011). First tests in the application of silicon photomultiplier arrays to dose monitoring in hadron therapy. Nucl. Instrum. Methods Phys. Res. A, 648, S96–S99.
Abstract: A detector head composed of a continuous LaBr3 crystal coupled to a silicon photomultiplier array has been mounted and tested, for its use in a Compton telescope for dose monitoring in hadron therapy. The LaBr3 crystal has 16 mm x 18 mm x 5 mm size, and it is surrounded with reflecting material in five faces. The SiPM array has 16 (4 x 4) elements of 3 mm x 3 mm size. The SPIROC1 ASIC has been employed as readout electronics. The detector shows a linear behavior up to 1275 keV. The energy resolution obtained at 511 keV is 7% FWHM, and it varies as one over the square root of the energy up to the energies tested. The variations among the detector channels are within 12%. A preliminary measurement of the timing resolution gives 7 ns FWHM. The spatial resolution obtained with the center of gravity method is 1.2 mm FWHM. The tests performed confirm the correct functioning of the detector.
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Llosa, G., Trovato, M., Barrio, J., Etxebeste, A., Muñoz, E., Lacasta, C., et al. (2016). First Images of a Three-layer compton Telescope prototype for Treatment Monitoring in hadron Therapy. Front. Oncol., 6, 14–6pp.
Abstract: A Compton telescope for dose monitoring in hadron therapy is under development at IFIC. The system consists of three layers of LaBr3 crystals coupled to silicon photomulti-plier arrays. Na-22 sources have been successfully imaged reconstructing the data with an ML-EM code. Calibration and temperature stabilization are necessary for the prototype operation at low coincidence rates. A spatial resolution of 7.8 mm FWHM has been obtained in the first imaging tests.
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Llosa, G., Barrio, J., Cabello, J., Crespo, A., Lacasta, C., Rafecas, M., et al. (2012). Detector characterization and first coincidence tests of a Compton telescope based on LaBr3 crystals and SiPMs. Nucl. Instrum. Methods Phys. Res. A, 695, 105–108.
Abstract: A Compton telescope for dose monitoring in hadron therapy consisting of several layers of continuous LaBr3 crystals coupled to silicon photomultiplier (SiPM) arrays is under development within the ENVISION project. In order to test the possibility of employing such detectors for the telescope, a detector head consisting of a continuous 16 mm x 18 mm x 5 mm LaBr3 crystal coupled to a SiPM array has been assembled and characterized, employing the SPIROC1 ASIC as readout electronics. The best energy resolution obtained at 511 key is 6.5% FWHM and the timing resolution is 3.1 ns FWHM. A position determination method for continuous crystals is being tested, with promising results. In addition, the detector has been operated in time coincidence with a second detector layer, to determine the coincidence capabilities of the system. The first tests are satisfactory, and encourage the development of larger detectors that will compose the telescope prototype.
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