| Records |
| Author |
Tetrault, M.A.; Oliver, J.F.; Bergeron, M.; Lecomte, R.; Fontaine, R. |
| Title |
Real Time Coincidence Detection Engine for High Count Rate Timestamp Based PET |
Type |
Journal Article |
| Year |
2010 |
Publication |
IEEE Transactions on Nuclear Science |
Abbreviated Journal  |
IEEE Trans. Nucl. Sci. |
| Volume |
57 |
Issue |
1 |
Pages |
117-124 |
| Keywords |
Coincidence detection; Positron Emission Tomography (PET) |
| Abstract |
Coincidence engines follow two main implementation flows: timestamp based systems and AND-gate based systems. The latter have been more widespread in recent years because of its lower cost and high efficiency. However, they are highly dependent on the selected electronic components, they have limited flexibility once assembled and they are customized to fit a specific scanner's geometry. Timestamp based systems are gathering more attention lately, especially with high channel count fully digital systems. These new systems must however cope with important singles count rates. One option is to record every detected event and postpone coincidence detection offline. For daily use systems, a real time engine is preferable because it dramatically reduces data volume and hence image preprocessing time and raw data management. This paper presents the timestamp based coincidence engine for the LabPET(TM), a small animal PET scanner with up to 4608 individual readout avalanche photodiode channels. The engine can handle up to 100 million single events per second and has extensive flexibility because it resides in programmable logic devices. It can be adapted for any detector geometry or channel count, can be ported to newer, faster programmable devices and can have extra modules added to take advantage of scanner-specific features. Finally, the user can select between full processing mode for imaging protocols and minimum processing mode to study different approaches for coincidence detection with offline software. |
| Address |
[Tetrault, M. -A.; Fontaine, R.] Univ Sherbrooke, Dept Elect & Comp Engn, Sherbrooke, PQ J1K 2R1, Canada, Email: Marc-Andre.Tetrault@USherbrooke.ca |
| Corporate Author |
|
Thesis |
|
| Publisher |
Ieee-Inst Electrical Electronics Engineers Inc |
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
0018-9499 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
ISI:000274391000016 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ elepoucu @ |
Serial |
500 |
| Permanent link to this record |
| |
|
| |
| Author |
Blume, M.; Martinez-Moller, A.; Keil, A.; Navab, N.; Rafecas, M. |
| Title |
Joint Reconstruction of Image and Motion in Gated Positron Emission Tomography |
Type |
Journal Article |
| Year |
2010 |
Publication |
IEEE Transactions on Medical Imaging |
Abbreviated Journal |
IEEE Trans. Med. Imaging |
| Volume |
29 |
Issue |
11 |
Pages |
1892-1906 |
| Keywords |
Gating; motion compensation; positron emission tomography (PET); reconstruction |
| Abstract |
We present a novel intrinsic method for joint reconstruction of both image and motion in positron emission tomography (PET). Intrinsic motion compensation methods exclusively work on the measured data, without any external motion measurements. Most of these methods separate image from motion estimation: They use deformable image registration/optical flow techniques in order to estimate the motion from individually reconstructed gates. Then, the image is estimated based on this motion information. With these methods, a main problem lies in the motion estimation step, which is based on the noisy gated frames. The more noise is present, the more inaccurate the image registration becomes. As we show both visually and quantitatively, joint reconstruction using a simple deformation field motion model can compete with state-of-the-art image registration methods which use robust multilevel B-spline motion models. |
| Address |
[Blume, Moritz; Rafecas, Magdalena] Univ Valencia, CSIC, IFIC, E-46071 Valencia, Spain, Email: moritz.blume@cs.tum.edu |
| Corporate Author |
|
Thesis |
|
| Publisher |
Ieee-Inst Electrical Electronics Engineers Inc |
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
0278-0062 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
ISI:000283941800007 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ elepoucu @ |
Serial |
340 |
| Permanent link to this record |
| |
|
| |
| Author |
Peris, J.B.; Davis, P.; Cuevas, J.M.; Nebot, M.; Sanjuan, R. |
| Title |
Distribution of Fitness Effects Caused by Single-Nucleotide Substitutions in Bacteriophage f1 |
Type |
Journal Article |
| Year |
2010 |
Publication |
Genetics |
Abbreviated Journal |
Genetics |
| Volume |
185 |
Issue |
2 |
Pages |
603-U308 |
| Keywords |
|
| Abstract |
Empirical knowledge of the fitness effects of mutations is important for understanding many evolutionary processes, yet this knowledge is often hampered by several sources of measurement error and bias. Most of these problems can be solved using site-directed mutagenesis to engineer single mutations, an approach particularly suited for viruses due to their small genomes. Here, we used this technique to measure the fitness effect of 100 single-nucleotide substitutions in the bacteriophage f1, a filamentous single-strand DNA virus. We found that approximately one-fifth of all mutations are lethal. Viable ones reduced fitness by 11% on average and were accurately described by a log-normal distribution. More than 90% of synonymous substitutions were selectively neutral, while those affecting intergenic regions reduced fitness by 14% on average. Mutations leading to amino acid substitutions had an overall mean deleterious effect of 37%, which increased to 45% for those changing the amino acid polarity. Interestingly, mutations affecting early steps of the infection cycle tended to be more deleterious than those affecting late steps. Finally, we observed at least two beneficial mutations. Our results confirm that high mutational sensitivity is a general property of viruses with small genomes, including RNA and single-strand DNA viruses infecting animals, plants, and bacteria. |
| Address |
[Peris, Joan B.; Davis, Paulina; Cuevas, Jose M.; Sanjuan, Rafael] Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolut, Valencia 46980, Spain, Email: rafael.sanjuan@uv.es |
| Corporate Author |
|
Thesis |
|
| Publisher |
Genetics Soc Am |
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
0016-6731 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
ISI:000281905200017 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
no |
| Call Number |
IFIC @ elepoucu @ |
Serial |
383 |
| Permanent link to this record |
| |
|
| |
| Author |
Mendez, V.; Amoros, G.; Garcia, F.; Salt, J. |
| Title |
Emergent algorithms for replica location and selection in data grid |
Type |
Journal Article |
| Year |
2010 |
Publication |
Future Generation Computer Systems |
Abbreviated Journal |
Futur. Gener. Comp. Syst. |
| Volume |
26 |
Issue |
7 |
Pages |
934-946 |
| Keywords |
Grid computing; Algorithms; Optimization methods; Artificial intelligence |
| Abstract |
Grid infrastructures for e-Science projects are growing in magnitude terms. Improvements in data Grid replication algorithms may be critical in many of these infrastructures. This paper shows a decentralized replica optimization service, providing a general Emergent Artificial Intelligence (EAI) algorithm for the problem definition. Our aim is to set up a theoretical framework for emergent heuristics in Grid environments. Further, we describe two EAI approaches, the Particle Swarm Optimization PSO-Grid Multiswarm Federation and the Ant Colony Optimization ACO-Grid Asynchronous Colonies Optimization replica optimization algorithms, with some examples. We also present extended results with best performance and scalability features for PSO-Grid Multiswarrn Federation. |
| Address |
[Mendez Munoz, Victor; Amoros Vicente, Gabriel; Salt Cairols, Jose] CSIC, Grid & E Sci Grp, Inst Fis Corpuscular IFIC, Mixed Inst, E-46071 Valencia, Spain, Email: vmendez@ific.uv.es |
| Corporate Author |
|
Thesis |
|
| Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
0167-739x |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
ISI:000279804200004 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
no |
| Call Number |
IFIC @ elepoucu @ |
Serial |
411 |
| Permanent link to this record |
| |
|
| |
| Author |
Rodriguez, D. et al; Algora, A.; Rubio, B.; Tain, J.L. |
| Title |
MATS and LaSpec: High-precision experiments using ion traps and lasers at FAIR |
Type |
Journal Article |
| Year |
2010 |
Publication |
European Physical Journal-Special Topics |
Abbreviated Journal |
Eur. Phys. J.-Spec. Top. |
| Volume |
183 |
Issue |
|
Pages |
1-123 |
| Keywords |
|
| Abstract |
Nuclear ground state properties including mass, charge radii, spins and moments can be determined by applying atomic physics techniques such as Penning-trap based mass spectrometry and laser spectroscopy. The MATS and LaSpec setups at the low-energy beamline at FAIR will allow us to extend the knowledge of these properties further into the region far from stability. The mass and its inherent connection with the nuclear binding energy is a fundamental property of a nuclide, a unique “fingerprint”. Thus, precise mass values are important for a variety of applications, ranging from nuclear-structure studies like the investigation of shell closures and the onset of deformation, tests of nuclear mass models and mass formulas, to tests of the weak interaction and of the Standard Model. The required relative accuracy ranges from 10(-5) to below 10(-8) for radionuclides, which most often have half-lives well below 1 s. Substantial progress in Penning trap mass spectrometry has made this method a prime choice for precision measurements on rare isotopes. The technique has the potential to provide high accuracy and sensitivity even for very short-lived nuclides. Furthermore, ion traps can be used for precision decay studies and offer advantages over existing methods. With MATS (Precision Measurements of very short-lived nuclei using an Advanced Trapping System for highly-charged ions) at FAIR we aim to apply several techniques to very short-lived radionuclides: High-accuracy mass measurements, in-trap conversion electron and alpha spectroscopy, and trap-assisted spectroscopy. The experimental setup of MATS is a unique combination of an electron beam ion trap for charge breeding, ion traps for beam preparation, and a high-precision Penning trap system for mass measurements and decay studies. For the mass measurements, MATS offers both a high accuracy and a high sensitivity. A relative mass uncertainty of 10(-9) can be reached by employing highly-charged ions and a non-destructive Fourier-Transform Ion-Cyclotron-Resonance (FT-ICR) detection technique on single stored ions. This accuracy limit is important for fundamental interaction tests, but also allows for the study of the fine structure of the nuclear mass surface with unprecedented accuracy, whenever required. The use of the FT-ICR technique provides true single ion sensitivity. This is essential to access isotopes that are produced with minimum rates which are very often the most interesting ones. Instead of pushing for highest accuracy, the high charge state of the ions can also be used to reduce the storage time of the ions, hence making measurements on even shorter-lived isotopes possible. Decay studies in ion traps will become possible with MATS. Novel spectroscopic tools for in-trap high-resolution conversion-electron and charged-particle spectroscopy from carrier-free sources will be developed, aiming e. g. at the measurements of quadrupole moments and E0 strengths. With the possibility of both high-accuracy mass measurements of the shortest-lived isotopes and decay studies, the high sensitivity and accuracy potential of MATS is ideally suited for the study of very exotic nuclides that will only be produced at the FAIR facility. Laser spectroscopy of radioactive isotopes and isomers is an efficient and model-independent approach for the determination of nuclear ground and isomeric state properties. Hyperfine structures and isotope shifts in electronic transitions exhibit readily accessible information on the nuclear spin, magnetic dipole and electric quadrupole moments as well as root-mean-square charge radii. The dependencies of the hyperfine splitting and isotope shift on the nuclear moments and mean square nuclear charge radii are well known and the theoretical framework for the extraction of nuclear parameters is well established. These extracted parameters provide fundamental information on the structure of nuclei at the limits of stability. Vital information on both bulk and valence nuclear properties are derived and an exceptional sensitivity to changes in nuclear deformation is achieved. Laser spectroscopy provides the only mechanism for such studies in exotic systems and uniquely facilitates these studies in a model-independent manner. The accuracy of laser-spectroscopic-determined nuclear properties is very high. Requirements concerning production rates are moderate; collinear spectroscopy has been performed with production rates as few as 100 ions per second and laser-desorption resonance ionization mass spectroscopy (combined with beta-delayed neutron detection) has been achieved with rates of only a few atoms per second. This Technical Design Report describes a new Penning trap mass spectrometry setup as well as a number of complementary experimental devices for laser spectroscopy, which will provide a complete system with respect to the physics and isotopes that can be studied. Since MATS and LaSpec require high-quality low-energy beams, the two collaborations have a common beamline to stop the radioactive beam of in-flight produced isotopes and prepare them in a suitable way for transfer to the MATS and LaSpec setups, respectively. |
| Address |
[Rodriguez, D.; Lallena, A. M.] Univ Granada, Dept Fis Atom Mol & Nucl, E-18071 Granada, Spain, Email: danielrodriguez@ugr.es |
| Corporate Author |
|
Thesis |
|
| Publisher |
Springer Heidelberg |
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1951-6355 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
ISI:000280061400001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ elepoucu @ |
Serial |
412 |
| Permanent link to this record |
