| Records |
| Author |
Bernabeu, J.; Botella, F.J.; Nebot, M.; Segarra, A. |
| Title |
B-0 – (B)over-bar(0) entanglement for an ideal experiment for the direct CP violation phi(3)/gamma phase |
Type |
Journal Article |
| Year |
2022 |
Publication |
Physical Review D |
Abbreviated Journal  |
Phys. Rev. D |
| Volume |
106 |
Issue |
5 |
Pages |
054026 - 7pp |
| Keywords |
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| Abstract |
B-0-(B) over bar0 entanglement offers a conceptual alternative to the single charged B-decay asymmetry for the measurement of the direct CP-violating gamma/phi(3) phase. With f = J/Psi(L); J/Psi K-S and g = (pi pi)(0); (rho(L)rho(L))(0), the 16 time-ordered double-decay rate intensities to (f, g) depend on the relative phase between the f- and g-decay amplitudes given by gamma at tree level. Several constraining consistencies appear. An intrinsic accuracy of the method at the level of +/- 1 degrees could be achievable at Belle-II with an improved determination of the penguin amplitude to g channels from existing facilities. |
| Address |
[Bernabeu, Jose; Botella, Francisco J.; Nebot, Miguel] Univ Valencia, Dept Theoret Phys, Valencia 46100, Spain |
| Corporate Author |
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Thesis |
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| Publisher |
Amer Physical Soc |
Place of Publication |
|
Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
2470-0010 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
|
| Notes |
WOS:000882839300002 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
no |
| Call Number |
IFIC @ pastor @ |
Serial |
5406 |
| Permanent link to this record |
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| Author |
Sanjuan, R.; Nebot, M.; Peris, J.B.; Alcami, J. |
| Title |
Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1 |
Type |
Journal Article |
| Year |
2013 |
Publication |
Plos Biology |
Abbreviated Journal |
PLoS. Biol. |
| Volume |
11 |
Issue |
4 |
Pages |
e1001523 - 10pp |
| Keywords |
|
| Abstract |
The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive. |
| Address |
Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolut, Valencia, Spain, Email: rafael.sanjuan@uv.es |
| Corporate Author |
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Thesis |
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| Publisher |
Public Library Science |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
|
Edition |
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| ISSN |
1545-7885 |
ISBN |
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Medium |
|
| Area |
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Expedition |
|
Conference |
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| Notes |
WOS:000318687800003 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
no |
| Call Number |
IFIC @ pastor @ |
Serial |
1446 |
| Permanent link to this record |
