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Assam, I., Vijande, J., Ballester, F., Perez-Calatayud, J., Poppe, B., & Siebert, F. A. (2022). Evaluation of dosimetric effects of metallic artifact reduction and tissue assignment on Monte Carlo dose calculations for I-125 prostate implants. Med. Phys., 49, 6195–6208.
Abstract: Purpose Monte Carlo (MC) simulation studies, aimed at evaluating the magnitude of tissue heterogeneity in I-125 prostate permanent seed implant brachytherapy (BT), customarily use clinical post-implant CT images to generate a virtual representation of a realistic patient model (virtual patient model). Metallic artifact reduction (MAR) techniques and tissue assignment schemes (TAS) are implemented on the post-implant CT images to mollify metallic artifacts due to BT seeds and to assign tissue types to the voxels corresponding to the bright seed spots and streaking artifacts, respectively. The objective of this study is to assess the combined influence of MAR and TAS on MC absorbed dose calculations in post-implant CT-based phantoms. The virtual patient models used for I-125 prostate implant MC absorbed dose calculations in this study are derived from the CT images of an external radiotherapy prostate patient without BT seeds and prostatic calcifications, thus averting the need to implement MAR and TAS. Methods The geometry of the IsoSeed I25.S17plus source is validated by comparing the MC calculated results of the TG-43 parameters for the line source approximation with the TG-43U1S2 consensus data. Four MC absorbed dose calculations are performed in two virtual patient models using the egs_brachy MC code: (1) TG-43-based D-w,w-TG(43), (2) D-w,D-w-MBDC that accounts for interseed scattering and attenuation (ISA), (3) D-m,D-m that examines ISA and tissue heterogeneity by scoring absorbed dose in tissue, and (4) D-w,D-m that unlike D-m,D-m scores absorbed dose in water. The MC absorbed doses (1) and (2) are simulated in a TG-43 patient phantom derived by assigning the densities of every voxel to 1.00 g cm(-3) (water), whereas MC absorbed doses (3) and (4) are scored in the TG-186 patient phantom generated by mapping the mass density of each voxel to tissue according to a CT calibration curve. The MC absorbed doses calculated in this study are compared with VariSeed v8.0 calculated absorbed doses. To evaluate the dosimetric effect of MAR and TAS, the MC absorbed doses of this work (independent of MAR and TAS) are compared to the MC absorbed doses of different I-125 source models from previous studies that were calculated with different MC codes using post-implant CT-based phantoms generated by implementing MAR and TAS on post-implant CT images. Results The very good agreement of TG-43 parameters of this study and the published consensus data within 3% validates the geometry of the IsoSeed I25.S17plus source. For the clinical studies, the TG-43-based calculations show a D-90 overestimation of more than 4% compared to the more realistic MC methods due to ISA and tissue composition. The results of this work generally show few discrepancies with the post-implant CT-based dosimetry studies with respect to the D-90 absorbed dose metric parameter. These discrepancies are mainly Type B uncertainties due to the different I-125 source models and MC codes. Conclusions The implementation of MAR and TAS on post-implant CT images have no dosimetric effect on the I-125 prostate MC absorbed dose calculation in post-implant CT-based phantoms.
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Hirn, J., Garcia, J. E., Montesinos-Navarro, A., Sanchez-Martin, R., Sanz, V., & Verdu, M. (2022). A deep Generative Artificial Intelligence system to predict species coexistence patterns. Methods Ecol. Evol., 13, 1052–1061.
Abstract: Predicting coexistence patterns is a current challenge to understand diversity maintenance, especially in rich communities where these patterns' complexity is magnified through indirect interactions that prevent their approximation with classical experimental approaches. We explore cutting-edge Machine Learning techniques called Generative Artificial Intelligence (GenAI) to predict species coexistence patterns in vegetation patches, training generative adversarial networks (GAN) and variational AutoEncoders (VAE) that are then used to unravel some of the mechanisms behind community assemblage. The GAN accurately reproduces real patches' species composition and plant species' affinity to different soil types, and the VAE also reaches a high level of accuracy, above 99%. Using the artificially generated patches, we found that high-order interactions tend to suppress the positive effects of low-order interactions. Finally, by reconstructing successional trajectories, we could identify the pioneer species with larger potential to generate a high diversity of distinct patches in terms of species composition. Understanding the complexity of species coexistence patterns in diverse ecological communities requires new approaches beyond heuristic rules. Generative Artificial Intelligence can be a powerful tool to this end as it allows to overcome the inherent dimensionality of this challenge.
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Giare, W., Renzi, F., Melchiorri, A., Mena, O., & Di Valentino, E. (2022). Cosmological forecasts on thermal axions, relic neutrinos, and light elements. Mon. Not. Roy. Astron. Soc., 511(1), 1373–1382.
Abstract: One of the targets of future cosmic microwave background (CMB) and baryon acoustic oscillation measurements is to improve the current accuracy in the neutrino sector and reach a much better sensitivity on extra dark radiation in the early Universe. In this paper, we study how these improvements can be translated into constraining power for well-motivated extensions of the standard model of elementary particles that involve axions thermalized before the quantum chromodynamics (QCD) phase transition by scatterings with gluons. Assuming a fiducial Lambda cold dark matter cosmological model, we simulate future data for Stage-IV CMB-like and Dark Energy Spectroscopic Instrument (DESI)-like surveys and analyse a mixed scenario of axion and neutrino hot dark matter. We further account also for the effects of these QCD axions on the light element abundances predicted by big bang nucleosynthesis. The most constraining forecasted limits on the hot relic masses are m(a) less than or similar to 0.92 eV and n-ary sumation m(nu) less than or similar to 0.12 eV at 95 per cent Confidence Level, showing that future cosmic observations can substantially improve the current bounds, supporting multimessenger analyses of axion, neutrino, and primordial light element properties.
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LHCb Collaboration(Aaij, R. et al), Jashal, B. K., Martinez-Vidal, F., Oyanguren, A., Remon Alepuz, C., & Ruiz Vidal, J. (2022). Study of the doubly charmed tetraquark T-cc(+). Nat. Commun., 13(1), 3351–19pp.
Abstract: Quantum chromodynamics, the theory of the strong force, describes interactions of coloured quarks and gluons and the formation of hadronic matter. Conventional hadronic matter consists of baryons and mesons made of three quarks and quark-antiquark pairs, respectively. Particles with an alternative quark content are known as exotic states. Here a study is reported of an exotic narrow state in the (DD0)-D-0 pi(+) mass spectrum just below the D*+D-0 mass threshold produced in proton-proton collisions collected with the LHCb detector at the Large Hadron Collider. The state is consistent with the ground isoscalar T-cc(+), tetraquark with a quark content of cc (u) over bar(d) over bar and spin-parity quantum numbers J(P) =1(+). Study of the DD mass spectra disfavours interpretation of the resonance as the isovector state. The decay structure via intermediate off-shell D*(+) mesons is consistent with the observed D-0 pi(+) mass distribution. To analyse the mass of the resonance and its coupling to the DID system, a dedicated model is developed under the assumption of an isoscalar axial-vector T-cc(+), state decaying to the D*D channel. Using this model, resonance parameters including the pole position, scattering length, effective range and compositeness are determined to reveal important information about the nature of the T-cc(+), state. In addition, an unexpected dependence of the production rate on track multiplicity is observed.
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LHCb Collaboration(Aaij, R. et al), Henry, L., Jashal, B. K., Martinez-Vidal, F., Oyanguren, A., Remon Alepuz, C., et al. (2022). Precise determination of the B-s(0)-B-s(-0) oscillation frequency. Nat. Phys., 18, 54–58.
Abstract: Mesons comprising a beauty quark and strange quark can oscillate between particle (B-s(0)) and antiparticle (B-s(-0)) flavour eigenstates, with a frequency given by the mass difference between heavy and light mass eigenstates, Delta m(s). Here we present a measurement of Delta m(s) using B-s(0) -> D-s(-)pi(+) decays produced in proton-proton collisions collected with the LHCb detector at the Large Hadron Collider. The oscillation frequency is found to be Delta m(s) = 17.7683 +/- 0.0051 +/- 0.0032 ps(-1), where the first uncertainty is statistical and the second is systematic. This measurement improves on the current Delta m(s) precision by a factor of two. We combine this result with previous LHCb measurements to determine Delta m(s) = 17.7656 +/- 0.0057 ps(-1), which is the legacy measurement of the original LHCb detector.
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