TY  - JOUR
AU  - Baran, J. et al
AU  - Brzezinski, K.
PY  - 2024
DA  - 2024//
TI  - Feasibility of the J-PET to monitor the range of therapeutic proton beams
T2  - Phys. Medica
JO  - Physica Medica
SP  - 103301
EP  - 9pp
VL  - 118
PB  - Elsevier Sci Ltd
KW  - PET
KW  - Range monitoring
KW  - J-PET
KW  - Monte Carlo simulations
KW  - Proton radiotherapy
AB  - Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J -PET) scanner for intra-treatment proton beam range monitoring. Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J -PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread -Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J -PET scanner prototype dedicated to the proton beam range assessment. Results: The investigations indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10-5 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple -layer dual -head geometry. The results indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for the clinical application, Conclusions: We performed simulation studies demonstrating that the feasibility of the J -PET detector for PET -based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre -clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double -layer cylindrical and triple -layer dual -head J -PET geometry configurations seem promising for future clinical application.
SN  - 1120-1797
UR  - https://arxiv.org/abs/2302.14359
UR  - https://doi.org/10.1016/j.ejmp.2024.103301
DO  - 10.1016/j.ejmp.2024.103301
LA  - English
N1  - WOS:001178648400001
ID  - Baran+Brzezinski2024
ER  -