%0 Journal Article
%T Feasibility of the J-PET to monitor the range of therapeutic proton beams
%A Baran, J. et al
%A Brzezinski, K.
%J Physica Medica
%D 2024
%V 118
%I Elsevier Sci Ltd
%@ 1120-1797
%G English
%F Baran+Brzezinski2024
%O WOS:001178648400001
%O exported from refbase (https://references.ific.uv.es/refbase/show.php?record=5990), last updated on Wed, 27 Mar 2024 16:16:36 +0000
%X Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J -PET) scanner for intra-treatment proton beam range monitoring. Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J -PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread -Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J -PET scanner prototype dedicated to the proton beam range assessment. Results: The investigations indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10-5 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple -layer dual -head geometry. The results indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for the clinical application, Conclusions: We performed simulation studies demonstrating that the feasibility of the J -PET detector for PET -based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre -clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double -layer cylindrical and triple -layer dual -head J -PET geometry configurations seem promising for future clinical application.
%K PET
%K Range monitoring
%K J-PET
%K Monte Carlo simulations
%K Proton radiotherapy
%R 10.1016/j.ejmp.2024.103301
%U https://arxiv.org/abs/2302.14359
%U https://doi.org/10.1016/j.ejmp.2024.103301
%P 103301-9pp