@Article{Baran+Brzezinski2024,
author="Baran, J. et al
and Brzezinski, K.",
title="Feasibility of the J-PET to monitor the range of therapeutic proton beams",
journal="Physica Medica",
year="2024",
publisher="Elsevier Sci Ltd",
volume="118",
pages="103301--9pp",
optkeywords="PET; Range monitoring; J-PET; Monte Carlo simulations; Proton radiotherapy",
abstract="Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J -PET) scanner for intra-treatment proton beam range monitoring. Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J -PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread -Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup{\textquoteright}s cost-effectiveness, we indicated potentially optimal geometries for the J -PET scanner prototype dedicated to the proton beam range assessment. Results: The investigations indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10-5 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple -layer dual -head geometry. The results indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for the clinical application, Conclusions: We performed simulation studies demonstrating that the feasibility of the J -PET detector for PET -based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre -clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double -layer cylindrical and triple -layer dual -head J -PET geometry configurations seem promising for future clinical application.",
optnote="WOS:001178648400001",
optnote="exported from refbase (https://references.ific.uv.es/refbase/show.php?record=5990), last updated on Wed, 27 Mar 2024 16:16:36 +0000",
issn="1120-1797",
doi="10.1016/j.ejmp.2024.103301",
opturl="https://arxiv.org/abs/2302.14359",
opturl="https://doi.org/10.1016/j.ejmp.2024.103301",
language="English"
}