TY  - JOUR
AU  - Solevi, P.
AU  - Muñoz, E.
AU  - Solaz, C.
AU  - Trovato, M.
AU  - Dendooven, P.
AU  - Gillam, J. E.
AU  - Lacasta, C.
AU  - Oliver, J. F.
AU  - Rafecas, M.
AU  - Torres-Espallardo, I.
AU  - Llosa, G.
PY  - 2016
DA  - 2016//
TI  - Performance of MACACO Compton telescope for ion-beam therapy monitoring: first test with proton beams
T2  - Phys. Med. Biol.
JO  - Physics in Medicine and Biology
SP  - 5149
EP  - 5165
VL  - 61
IS  - 14
PB  - Iop Publishing Ltd
KW  - ion-beam therapy
KW  - range verification
KW  - prompt gamma
KW  - Compton camera
KW  - GATE
AB  - In order to exploit the advantages of ion-beam therapy in a clinical setting, delivery verification techniques are necessary to detect deviations from the planned treatment. Efforts are currently oriented towards the development of devices for real-time range monitoring. Among the different detector concepts proposed, Compton cameras are employed to detect prompt gammas and represent a valid candidate for real-time range verification. We present the first on-beam test of MACACO, a Compton telescope (multi-layer Compton camera) based on lanthanum bromide crystals and silicon photo-multipliers. The Compton telescope was first characterized through measurements and Monte Carlo simulations. The detector linearity was measured employing Na-22 and Am-Be sources, obtaining about 10% deviation from linearity at 3.44 MeV. A spectral image reconstruction algorithm was tested on synthetic data. Point-like sources emitting gamma rays with energy between 2 and 7 MeV were reconstructed with 3-5 mm resolution. The two-layer Compton telescope was employed to measure radiation emitted from a beam of 150 MeV protons impinging on a cylindrical PMMA target. Bragg-peak shifts were achieved via adjustment of the PMMA target location and the resulting measurements used during image reconstruction. Reconstructed Bragg peak profiles proved sufficient to observe peak-location differences within 10 mm demonstrating the potential of the MACACO Compton Telescope as a monitoring device for ion-beam therapy.
SN  - 0031-9155
UR  - https://doi.org/10.1088/0031-9155/61/14/5149
DO  - 10.1088/0031-9155/61/14/5149
LA  - English
N1  - WOS:000379555300007
ID  - Solevi_etal2016
ER  -