%0 Journal Article
%T Performance of MACACO Compton telescope for ion-beam therapy monitoring: first test with proton beams
%A Solevi, P.
%A Muñoz, E.
%A Solaz, C.
%A Trovato, M.
%A Dendooven, P.
%A Gillam, J. E.
%A Lacasta, C.
%A Oliver, J. F.
%A Rafecas, M.
%A Torres-Espallardo, I.
%A Llosa, G.
%J Physics in Medicine and Biology
%D 2016
%V 61
%N 14
%I Iop Publishing Ltd
%@ 0031-9155
%G English
%F Solevi_etal2016
%O WOS:000379555300007
%O exported from refbase (https://references.ific.uv.es/refbase/show.php?record=2754), last updated on Fri, 12 Jun 2020 07:51:36 +0000
%X In order to exploit the advantages of ion-beam therapy in a clinical setting, delivery verification techniques are necessary to detect deviations from the planned treatment. Efforts are currently oriented towards the development of devices for real-time range monitoring. Among the different detector concepts proposed, Compton cameras are employed to detect prompt gammas and represent a valid candidate for real-time range verification. We present the first on-beam test of MACACO, a Compton telescope (multi-layer Compton camera) based on lanthanum bromide crystals and silicon photo-multipliers. The Compton telescope was first characterized through measurements and Monte Carlo simulations. The detector linearity was measured employing Na-22 and Am-Be sources, obtaining about 10% deviation from linearity at 3.44 MeV. A spectral image reconstruction algorithm was tested on synthetic data. Point-like sources emitting gamma rays with energy between 2 and 7 MeV were reconstructed with 3-5 mm resolution. The two-layer Compton telescope was employed to measure radiation emitted from a beam of 150 MeV protons impinging on a cylindrical PMMA target. Bragg-peak shifts were achieved via adjustment of the PMMA target location and the resulting measurements used during image reconstruction. Reconstructed Bragg peak profiles proved sufficient to observe peak-location differences within 10 mm demonstrating the potential of the MACACO Compton Telescope as a monitoring device for ion-beam therapy.
%K ion-beam therapy
%K range verification
%K prompt gamma
%K Compton camera
%K GATE
%R 10.1088/0031-9155/61/14/5149
%U https://doi.org/10.1088/0031-9155/61/14/5149
%P 5149-5165