@Article{Solevi_etal2016,
author="Solevi, P.
and Mu{\~{n}}oz, E.
and Solaz, C.
and Trovato, M.
and Dendooven, P.
and Gillam, J. E.
and Lacasta, C.
and Oliver, J. F.
and Rafecas, M.
and Torres-Espallardo, I.
and Llosa, G.",
title="Performance of MACACO Compton telescope for ion-beam therapy monitoring: first test with proton beams",
journal="Physics in Medicine and Biology",
year="2016",
publisher="Iop Publishing Ltd",
volume="61",
number="14",
pages="5149--5165",
optkeywords="ion-beam therapy; range verification; prompt gamma; Compton camera; GATE",
abstract="In order to exploit the advantages of ion-beam therapy in a clinical setting, delivery verification techniques are necessary to detect deviations from the planned treatment. Efforts are currently oriented towards the development of devices for real-time range monitoring. Among the different detector concepts proposed, Compton cameras are employed to detect prompt gammas and represent a valid candidate for real-time range verification. We present the first on-beam test of MACACO, a Compton telescope (multi-layer Compton camera) based on lanthanum bromide crystals and silicon photo-multipliers. The Compton telescope was first characterized through measurements and Monte Carlo simulations. The detector linearity was measured employing Na-22 and Am-Be sources, obtaining about 10{\%} deviation from linearity at 3.44 MeV. A spectral image reconstruction algorithm was tested on synthetic data. Point-like sources emitting gamma rays with energy between 2 and 7 MeV were reconstructed with 3-5 mm resolution. The two-layer Compton telescope was employed to measure radiation emitted from a beam of 150 MeV protons impinging on a cylindrical PMMA target. Bragg-peak shifts were achieved via adjustment of the PMMA target location and the resulting measurements used during image reconstruction. Reconstructed Bragg peak profiles proved sufficient to observe peak-location differences within 10 mm demonstrating the potential of the MACACO Compton Telescope as a monitoring device for ion-beam therapy.",
optnote="WOS:000379555300007",
optnote="exported from refbase (https://references.ific.uv.es/refbase/show.php?record=2754), last updated on Fri, 12 Jun 2020 07:51:36 +0000",
issn="0031-9155",
doi="10.1088/0031-9155/61/14/5149",
opturl="https://doi.org/10.1088/0031-9155/61/14/5149",
language="English"
}