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Di Gregorio, E., Staelens, M., Hosseinkhah, N., Karimpoor, M., Liburd, J., Lim, L., et al. (2024). Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases. Nanomaterials, 14(13), 1093–21pp.
Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.
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Pich, A., Solomonidi, E., & Vale Silva, L. (2023). Final-state interactions in the CP asymmetries of charm-meson two-body decays. Phys. Rev. D, 108, 036026–25pp.
Abstract: Urgent theoretical progress is needed in order to provide an estimate in the Standard Model of the recent measurement by LHCb of direct CP violation in charm-meson two-body decays. Rescattering effects must be taken into account for a meaningful theoretical description of the amplitudes involved in such category of observables, as signaled by the presence of large strong phases. We discuss the computation of the latter effects based on a two-channel coupled dispersion relation, which exploits isospin-zero phase shifts and inelasticity parametrizations of data coming from the rescattering processes ππ→ππ, πK→πK, and ππ→K¯K. The determination of the subtraction constants of the dispersive integrals relies on the leading contributions to the transition amplitudes from the 1/NC counting, where NC is the number of QCD colors. Furthermore, we use the measured values of the branching ratios to help in selecting the nonperturbative inputs in the isospin limit, from which we predict values for the CP asymmetries. We find that the predicted level of CP violation is much below the experimental value.
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Sanchis-Gual, N., & del Rio, A. (2023). Precessing binary black holes as engines of electromagnetic helicity. Phys. Rev. D, 108, 044052–11pp.
Abstract: We show that binary black hole mergers with precessing evolution can potentially excite photons from the quantum vacuum in such a way that total helicity is not preserved in the process. Helicity violation is allowed by quantum fluctuations that spoil the electric-magnetic duality symmetry of the classical Maxwell theory without charges. We show here that precessing binary black hole systems in astrophysics generate a flux of circularly polarized gravitational waves which, in turn, provides the required helical background that triggers this quantum effect. Solving the fully nonlinear Einstein’s equations with numerical relativity we explore the parameter space of binary systems and extract the detailed dependence of the quantum effect with the spins of the two black holes. We also introduce a set of diagrammatic techniques that allows us to predict when a binary black hole merger can or cannot emit circularly polarized gravitational radiation, based on mirror-symmetry considerations. This framework allows to understand and to interpret correctly the numerical results, and to predict the outcomes in potentially interesting astrophysical systems.
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Balbinot, R., & Fabbri, A. (2023). Quantum energy momentum tensor and equal time correlations in a Reissner-Nordström black hole. Phys. Rev. D, 108, 045004–9pp.
Abstract: We consider a Reissner-Nordström black hole formed by the collapse of a charged null shell. The renormalized expectation values of the energy-momentum tensor operator for a massless scalar field propagating in the two-dimensional section of this spacetime are given. We then analyze the across-the-horizon correlations of the related energy density operator for free-falling observers to reveal the correlations between the Hawking particles and their interior partners.
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Winney, D., Fernandez-Ramirez, C., Pilloni, A., Hiller Blin, A. N., Albaladejo, M., Bibrzycki, L., et al. (2023). Dynamics in near-threshold J/ψ photoproduction. Phys. Rev. D, 108, 054018–15pp.
Abstract: The study of J/ψ photoproduction at low energies has consequences for the understanding of multiple aspects of nonperturbative QCD, ranging from mechanical properties of the proton to the binding inside nuclei and the existence of hidden-charm pentaquarks. Factorization of the photon-c¯c and nucleon dynamics or vector meson dominance are often invoked to justify these studies. Alternatively, open-charm intermediate states have been proposed as the dominant mechanism underlying J/ψ photoproduction. As the latter violates this factorization, it is important to estimate the relevance of such contributions. We analyze the latest differential and integrated photoproduction cross sections from the GlueX and J/ψ−007 experiments. We show that the data can be adequately described by a small number of partial waves, which we parametrize with generic models enforcing low-energy unitarity. The results suggest a non-negligible contribution from open-charm intermediate states. Furthermore, most of the models present an elastic scattering length incompatible with previous extractions based on vector meson dominance and thus call into question its applicability to heavy mesons. Our results indicate a wide array of physics possibilities that are compatible with present data and need to be disentangled.
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Dorigo, T. et al, Ramos, A., & Ruiz de Austri, R. (2023). Toward the end-to-end optimization of particle physics instruments with differentiable programming. Rev. Phys., 10, 100085– pp.
Abstract: The full optimization of the design and operation of instruments whose functioning relies on the interaction of radiation with matter is a super-human task, due to the large dimensionality of the space of possible choices for geometry, detection technology, materials, data-acquisition, and information-extraction techniques, and the interdependence of the related parameters. On the other hand, massive potential gains in performance over standard, “experience-driven” layouts are in principle within our reach if an objective function fully aligned with the final goals of the instrument is maximized through a systematic search of the configuration space. The stochastic nature of the involved quantum processes make the modeling of these systems an intractable problem from a classical statistics point of view, yet the construction of a fully differentiable pipeline and the use of deep learning techniques may allow the simultaneous optimization of all design parameters.
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Bernabeu, J., Sabulsky, D. O., Sanchez, F., & Segarra, A. (2024). Neutrino mass and nature through its mediation in atomic clock interference. AVS Quantum Sci., 6(1), 014410–8pp.
Abstract: The absolute mass of neutrinos and their nature are presently unknown. Aggregate matter has a coherent weak charge leading to a repulsive interaction mediated by a neutrino pair. The virtual neutrinos are non-relativistic at micron distances, giving a distinct behavior for Dirac versus Majorana mass terms. This effective potential allows for the disentanglement of the Dirac or Majorana nature of the neutrino via magnitude and distance dependence. We propose an experiment to search for this potential based on the concept that the density-dependent interaction of an atomic probe with a material source in one arm of an atomic clock interferometer generates a differential phase. The appropriate geometry of the device is selected using the saturation of the weak potential as a guide. The proposed experiment has the added benefit of being sensitive to gravity at micron distances. A strategy to suppress the competing Casimir-Polder interaction, depending on the electronic structure of the material source, as well as a way to compensate the gravitational interaction in the two arms of the interferometer is discussed.
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Das, B. et al, & Algora, A. (2024). Broken seniority symmetry in the semimagic proton mid-shell nucleus 95Rh. Phys. Rev. Res., 6(2), L022038–7pp.
Abstract: Lifetime measurements of low-lying excited states in the semimagic ( N = 50) nucleus 95 Rh have been performed by means of the fast -timing technique. The experiment was carried out using gamma -ray detector arrays consisting of LaBr 3 (Ce) scintillators and germanium detectors integrated into the DESPEC experimental setup commissioned for the Facility for Antiproton and Ion Research ( FAIR ) Phase -0, Darmstadt, Germany. The excited states in 95 Rh were populated primarily via the /3 decays of 95 Pd nuclei, produced in the projectile fragmentation of a 850 MeV / nucleon 124 Xe beam impinging on a 4 g / cm 2 9 Be target. The deduced electromagnetic E2 transition strengths for the gamma -ray cascade within the multiplet structure depopulating from the isomeric I pi = 21 / 2 + state are found to exhibit strong deviations from predictions of standard shell model calculations which feature approximately conserved seniority symmetry. In particular, the observation of a strongly suppressed E2 strength for the 13 / 2 + -> 9 / 2 + ground state transition cannot be explained by calculations employing standard interactions. This remarkable result may require revision of the nucleon-nucleon interactions employed in state-of-the-art theoretical model calculations, and might also point to the need for including three-body forces in the Hamiltonian.
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Maluf, R. V., Mora-Perez, G., Olmo, G. J., & Rubiera-Garcia, D. (2024). Nonsingular, Lump-like, Scalar Compact Objects in (2+1)-Dimensional Einstein Gravity. Universe, 10(6), 258–13pp.
Abstract: We study the space-time geometry generated by coupling a free scalar field with a noncanonical kinetic term to general relativity in (2+1) dimensions. After identifying a family of scalar Lagrangians that yield exact analytical solutions in static and circularly symmetric scenarios, we classify the various types of solutions and focus on a branch that yields asymptotically flat geometries. We show that the solutions within such a branch can be divided in two types, namely naked singularities and nonsingular objects without a center. In the latter, the energy density is localized around a maximum and vanishes only at infinity and at an inner boundary. This boundary has vanishing curvatures and cannot be reached by any time-like or null geodesic in finite affine time. This allows us to consistently interpret such solutions as nonsingular, lump-like, static compact scalar objects whose eventual extension to the (3+1)-dimensional context could provide structures of astrophysical interest.
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Araujo Filho, A. A., Jusufi, K., Cuadros-Melgar, B., & Leon, G. (2024). Dark matter signatures of black holes with Yukawa potential. Phys. Dark Universe, 44, 101500–20pp.
Abstract: This study uses a nonsingular Yukawa-modified potential to obtain a static and spherically symmetric black hole solution with a cosmological constant. Such Yukawa-like corrections are encoded in two parameters, alpha and lambda, that modify Newton's law of gravity in large distances, and a deformation parameter l(0), which plays an essential role in short distances. The most significant effect is encoded in alpha, which modifies the total black hole mass with an extra mass proportional to alpha M, mimicking the dark matter effects at large distances from the black hole. On the other hand, the effect due to lambda is small for astrophysical values. We scrutinize the quasinormal frequencies and shadows associated with a spherically symmetric black hole and the thermodynamical behavior influenced by the Yukawa potential. In particular, the thermodynamics of this black hole displays a rich behavior, including possible phase transitions. We use the WKB method to probe the quasinormal modes of massless scalar, electromagnetic, and gravitational field perturbations. In order to check the influence of the parameters on the shadow radius, we consider astrophysical data to determine their values, incorporating information on an optically thin radiating and infalling gas surrounding a black hole to model the black hole shadow image. In particular, we consider Sgr A* black hole as an example and we find that its shadow radius changes by order of 10(-9), meaning that the shadow radius of a black hole with Yukawa potential practically gives rise to the same result encountered in the Schwarzschild black hole. Also, in the eikonal regime, using astrophysical data for Yukawa parameters, we show that the value of the real part of the QNMs frequencies changes by 10(-18). Such Yukawa-like corrections are, therefore, difficult to measure by observations of gravitational waves using the current technology.
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