| Records |
| Author |
Albaladejo, M.; Nieves, J.; Ruiz Arriola, E. |
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Femtoscopic signatures of the lightest S-wave scalar open-charm mesons |
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Journal Article |
| Year |
2023 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
| Volume |
108 |
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Pages |
014020 - 7pp |
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| Abstract |
We predict femtoscopy correlation functions for S-wave D(s)ϕ pairs of lightest pseudoscalar open-charm mesons and Goldstone bosons from next-to-leading-order unitarized heavy-meson chiral perturbation theory amplitudes. The effect of the two-state structure around 2300 MeV can be clearly seen in the (S,I)=(0,1/2) Dπ, Dη, and Ds¯K correlation functions, while in the scalar-strange (1,0) sector, the D∗s0(2317)± state lying below the DK threshold produces a depletion of the correlation function near threshold. These exotic states owe their existence to the nonperturbative dynamics of Goldstone-boson scattering off D(s). The predicted correlation functions could be experimentally measured and will shed light into the hadron spectrum, confirming that it should be viewed as more than a collection of quark model states. |
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no |
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yes |
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no |
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IFIC @ pastor @ |
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6089 |
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| Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
| Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
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Journal Article |
| Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
| Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
| Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
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In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
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[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
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Mdpi |
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English |
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WOS:001269841000001 |
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no |
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yes |
International Collaboration |
yes |
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IFIC @ pastor @ |
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6204 |
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Pich, A.; Solomonidi, E.; Vale Silva, L. |
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Final-state interactions in the CP asymmetries of charm-meson two-body decays |
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Journal Article |
| Year |
2023 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
| Volume |
108 |
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036026 - 25pp |
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Urgent theoretical progress is needed in order to provide an estimate in the Standard Model of the recent measurement by LHCb of direct CP violation in charm-meson two-body decays. Rescattering effects must be taken into account for a meaningful theoretical description of the amplitudes involved in such category of observables, as signaled by the presence of large strong phases. We discuss the computation of the latter effects based on a two-channel coupled dispersion relation, which exploits isospin-zero phase shifts and inelasticity parametrizations of data coming from the rescattering processes ππ→ππ, πK→πK, and ππ→K¯K. The determination of the subtraction constants of the dispersive integrals relies on the leading contributions to the transition amplitudes from the 1/NC counting, where NC is the number of QCD colors. Furthermore, we use the measured values of the branching ratios to help in selecting the nonperturbative inputs in the isospin limit, from which we predict values for the CP asymmetries. We find that the predicted level of CP violation is much below the experimental value. |
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no |
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yes |
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no |
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IFIC @ pastor @ |
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6091 |
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Sanchis-Gual, N.; del Rio, A. |
| Title |
Precessing binary black holes as engines of electromagnetic helicity |
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Journal Article |
| Year |
2023 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
| Volume |
108 |
Issue |
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Pages |
044052 - 11pp |
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We show that binary black hole mergers with precessing evolution can potentially excite photons from the quantum vacuum in such a way that total helicity is not preserved in the process. Helicity violation is allowed by quantum fluctuations that spoil the electric-magnetic duality symmetry of the classical Maxwell theory without charges. We show here that precessing binary black hole systems in astrophysics generate a flux of circularly polarized gravitational waves which, in turn, provides the required helical background that triggers this quantum effect. Solving the fully nonlinear Einstein’s equations with numerical relativity we explore the parameter space of binary systems and extract the detailed dependence of the quantum effect with the spins of the two black holes. We also introduce a set of diagrammatic techniques that allows us to predict when a binary black hole merger can or cannot emit circularly polarized gravitational radiation, based on mirror-symmetry considerations. This framework allows to understand and to interpret correctly the numerical results, and to predict the outcomes in potentially interesting astrophysical systems. |
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no |
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yes |
International Collaboration |
yes |
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IFIC @ pastor @ |
Serial |
6092 |
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| Author |
Balbinot, R.; Fabbri, A. |
| Title |
Quantum energy momentum tensor and equal time correlations in a Reissner-Nordström black hole |
Type |
Journal Article |
| Year |
2023 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
| Volume |
108 |
Issue |
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Pages |
045004 - 9pp |
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We consider a Reissner-Nordström black hole formed by the collapse of a charged null shell. The renormalized expectation values of the energy-momentum tensor operator for a massless scalar field propagating in the two-dimensional section of this spacetime are given. We then analyze the across-the-horizon correlations of the related energy density operator for free-falling observers to reveal the correlations between the Hawking particles and their interior partners. |
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no |
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yes |
International Collaboration |
yes |
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IFIC @ pastor @ |
Serial |
6093 |
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